Article in Arteriosclerosis, thrombosis, and vascular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Guillermo MorenoFaculty of Nursing, Physiotherapy and Podiatry, Nursing Department (G.M.), Department of Immunology, Ophthalmology and ENT, School of Medicine, Universidad Complutense de Madrid.ORCID 0000-0003-2873-3874
Alberto BenguríaCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.).ORCID 0000-0002-5536-566X
Ana DopazoCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.).ORCID 0000-0002-4910-1684
Carlos TorrojaCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.).ORCID 0000-0001-8914-3400
Fernando Martínez de BenitoCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.).ORCID 0000-0003-1904-5164
Bianca CalìInstitut Curie and Institut Pierre-Gilles de Gennes, PSL Research University, Centre National de la Recherche Scientifique (CNRS), Unités Mixtes de Recherche (UMR) 144, Paris, France (B.C., P.V.).ORCID 0000-0002-9090-9992
Pablo VargasInstitut Curie and Institut Pierre-Gilles de Gennes, PSL Research University, Centre National de la Recherche Scientifique (CNRS), Unités Mixtes de Recherche (UMR) 144, Paris, France (B.C., P.V.).ORCID 0000-0002-6475-494X
Carlos Silvestre-RoigCenter for Molecular Biology of Inflammation (ZMBE), Institute of Experimental Pathology, University of Münster, Germany (C.S.-R.).ORCID 0000-0003-1169-7475
José M González-GranadoCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.D., F.M.d.B., J.M.G.-G., H.B., J.J.F., V.A.).ORCID 0000-0002-1177-869X
backgroundAging is the primary risk factor for atherosclerosis, a degenerative process regulated by immune cells and the leading cause of death worldwide. Previous studies on premature aging syndromes have linked atherosclerosis to defects in A-type lamins, key nuclear envelope components. However, whether these defects influence atherosclerosis during normal aging remains unexplored. Here, we examined how aging affects lamin A/C expression in circulating leukocytes and investigated the impact of manipulating their expression in hematopoietic cells on their function and atherosclerosis progression.
methodsFlow cytometry assessed lamin A/C expression in human circulating leukocytes. Bone marrow from donor mice was transplanted into lethally irradiated,
resultsHuman aging is associated with lower levels of lamin A/C expression in blood-borne leukocytes. To evaluate the functional relationship between hematopoietic lamin A/C expression and atherosclerosis development, we used
conclusionsWe suggest that the age-related decline in lamin A/C expression in blood-borne immune cells contributes to increased leukocyte extravasation and atherosclerosis, highlighting lamin A/C as a novel regulator of age-related atherosclerosis.
Indexed as
AgingAortic DiseasesAtherosclerosisHematopoietic Stem CellsLamin Type ALeukocytesAgedAge FactorsAnimalsAortaDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLLamin Type ALMNA protein, humanLmna protein, mouseReceptors, LDLagingatherosclerosiscardiovascular diseasesinflammationlamin type Asingle-cell gene expression analysis
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Lamin A/C Expression in Hematopoietic Cells Declines During Human Aging and Constrains Atherosclerosis in Mice. · full record | OpenQuestion