ArticleJournal of cell science2025
The adhesion plaque mediates fluid discharge and duplication of the contractile vacuole complex in Trypanosoma cruzi.
Article in Journal of cell science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Cell Death and Unprecedent Cytoskeletal Changes inChemical & biomedical imaging · 2026Article
- Cyclic AMP compartmentalization drives signal specificity to control vector colonization and mammalian host infection by American trypanosomes.PLoS pathogens · 2026Article
- Cyclic AMP compartmentalization drives signal specificity to control vector colonization and mammalian host infection by American trypanosomes.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
This work explores the intricate process of osmoregulation in Trypanosoma cruzi, the causative agent of Chagas disease, with a specific focus on the mechanisms of fluid discharge by the contractile vacuole complex (CVC) and the role of the adhesion plaque (AP), a structure whose densities are located in the membrane domain shared by the CVC and the flagellar pocket. Cryopreparation of T. cruzi samples, combined with volume electron microscopy techniques, allowed for a comprehensive analysis of the essential mechanisms underlying the structural changes that take place in the AP during osmotic stress. Remodeling of the AP coupled to membrane fusion events leads to the formation of pores that connect the flagellar pocket and the CVC. The fluid discharge process followed sequential steps of pore opening, expansion and closure, to allow membrane fusion. Additionally, this study uncovers structural variations in the CVC during cellular replication, providing insights into the cellular biology and physiology of trypanosomatids.
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Registered trials
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