Evidence map›Paper›PMID 40605594›Full record

ArticlePhysiological reports2025

Manganese-enhanced MRI during remotely induced myocardial ischemia reperfusion injury in male mice.

Matic Pusovnik, Michiel Algoet, Willy Gsell, Stefan Janssens, Wouter Oosterlinck, Uwe Himmelreich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matic PusovnikBiomedical MRI, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.ORCID 0000-0002-5731-4647
Michiel AlgoetDepartment of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
Willy GsellBruker Belgium, Kontich, Belgium.
Stefan JanssensDepartment of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
Wouter OosterlinckDepartment of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
Uwe HimmelreichBiomedical MRI, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.ORCID 0000-0002-2060-8895

Funding

Fonds Wetenschappelijk Onderzoek (FWO) 11A2423NFonds Wetenschappelijk Onderzoek (FWO) G0A7722NKU Leuven (Katholieke Universiteit Leuven) C14/20/095
6 · The paper itself

Abstract

Early assessment of myocardial viability post-ischemia is crucial to mitigate adverse remodeling and optimize therapy. Current noninvasive methods like late gadolinium enhancement (LGE) MRI may overestimate infarct size. Manganese-enhanced MRI (MEMRI) emerged as a promising alternative, offering greater specificity in assessing myocardial damage. We evaluated MEMRI alongside LGE and histology in a murine ischemia-reperfusion model using a novel "in-scanner" remote occlusion technique for real-time imaging during acute ischemia. Male C57BL/6 mice (n = 16) underwent left anterior descending artery occlusion (n = 7), sham surgery (n = 6), or no intervention (n = 3). MEMRI (0.1 mmol/kg MnCl

Indexed as

Contrast MediaMagnetic Resonance ImagingManganeseMyocardial Reperfusion InjuryAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLMyocardial InfarctionMyocardiumContrast MediaManganeseischemia–reperfusion injuryleft anterior descending arterymanganese enhanced magnetic resonance imagingmyocardial perfusionmyocardial remodeling

Identifiers

PMID40605594
PMCPMC12223404

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.