Evidence map›Paper›PMID 40605550›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Atrial Fibroblasts-Derived Extracellular Vesicles Exacerbate Atrial Arrhythmogenesis.

Yue Yuan, Xinbo Zhao, Xuejie Han, Yukai Cao, Xuexin Jin, Ling Shi, Xin Bi, Desheng Li, Yun Zhang, Wenbo Ma and 4 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Atrial Fibroblasts-Derived Extracellular Vesicles Exacerbate Atrial Arrhythmogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yue YuanDepartment of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin, 150001, China.
Xinbo ZhaoDepartment of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin, 150001, China.
Xuejie HanDepartment of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin, 150001, China.
Yukai CaoDepartment of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin, 150001, China.
Xuexin JinDepartment of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin, 150001, China.
Ling ShiDepartment of Pharmacology, Harbin Medical University, Harbin, 150086, China.
Xin BiDepartment of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin, 150001, China.
Desheng LiDepartment of Pharmacology, Harbin Medical University, Harbin, 150086, China.
Yun ZhangDepartment of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin, 150001, China.
Wenbo MaDepartment of Pharmacology, Harbin Medical University, Harbin, 150086, China.
Jiahui SongDepartment of Pharmacology, Harbin Medical University, Harbin, 150086, China.
Zhenwei PanDepartment of Pharmacology, Harbin Medical University, Harbin, 150086, China.
Zhiren ZhangDepartment of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin, 150001, China.
Yue LiDepartment of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin, 150001, China.ORCID https://orcid.org/0000-0002-2353-4078

Funding

Heilongjiang Provincial Postdoctoral Science Foundation LBH-Z18220National Natural Science Foundation of China 81830012National Natural Science Foundation of China 81900302National Natural Science Foundation of China 82330014Postdoctoral Research Foundation of China 2018M641869
6 · The paper itself

Abstract

Cardiac fibroblasts (CFs) secrete exosomes, and their cargo represents a new means of cellular communication in cardiovascular diseases, including atrial fibrillation (AF). We aimed to explore the contribution of atial CFs (ACFs)-derived exosomes to AF development. Cultured primary human ACFs (hACFs) and rat ACFs are treated with angiotensin II, and the secreted exosomes are transferred to rats. Action potential duration and L-type calcium current (I

Indexed as

Arrhythmias, CardiacAtrial FibrillationExtracellular VesiclesFibroblastsHeart AtriaAnimalsCalcium Channels, L-TypeCells, CulturedDisease Models, AnimalExosomesHumansMaleMiceMice, Inbred C57BLMicroRNAsRatsCalcium Channels, L-TypeMicroRNAsatrial fibrillationatrial fibroblastsCACNA1CexosomesmicroRNA‐224‐5p

Identifiers

PMID40605550
PMCPMC12499491

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.