Evidence map›Paper›PMID 40605511›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Harnessing the Immunomodulation of UV-Exposed Keratinocyte Extracellular Vesicles for Inflammatory Disorder Treatment.

Lu Liu, Ding Yang, Jingsen Ji, Gengyou Li, Haoting Chen, Yuying Yao, Chenxing Fu, Fangling Liao, Jinzhao Liu, Yaming Zhang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Exosomes in Psoriasis: From Pathogenic Mechanisms to Therapeutic Innovations.Clinical, cosmetic and investigational dermatology · 2026
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Lu LiuState Key Laboratory of Pharmaceutical Biotechnology, Department of Pharmacology and Pharmacy, and Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Hong Kong, 999077, China.
Ding YangKey laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiology, Peking University Cancer Hospital & Institute, Hai Dian, Beijing, 100142, China.
Jingsen JiDepartment of Minimally Invasive Interventional Radiology, The Second Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510260, China.
Gengyou LiDepartment of Minimally Invasive Interventional Radiology, The Second Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510260, China.
Haoting ChenDepartment of Minimally Invasive Interventional Radiology, The Second Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510260, China.
Yuying YaoDepartment of Minimally Invasive Interventional Radiology, The Second Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510260, China.
Chenxing FuDepartment of Minimally Invasive Interventional Radiology, The Second Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510260, China.
Fangling LiaoDepartment of Minimally Invasive Interventional Radiology, The Second Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510260, China.
Jinzhao LiuState Key Laboratory of Pharmaceutical Biotechnology, Department of Pharmacology and Pharmacy, and Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Hong Kong, 999077, China.
Yaming ZhangState Key Laboratory of Pharmaceutical Biotechnology, Department of Pharmacology and Pharmacy, and Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Hong Kong, 999077, China.
Zechuan LiDepartment of Minimally Invasive Interventional Radiology, The Second Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510260, China.
Jing ZhangDepartment of Minimally Invasive Interventional Radiology, The Second Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510260, China.
Huike MaBeijing Hospital of Traditional Chinese Medicine, Beijing Institute of Chinese Medicine, Capital Medical University, Beijing, 100010, China.
Jingxia ZhaoBeijing Hospital of Traditional Chinese Medicine, Beijing Institute of Chinese Medicine, Capital Medical University, Beijing, 100010, China.
Ying-Shi SunKey laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiology, Peking University Cancer Hospital & Institute, Hai Dian, Beijing, 100142, China.
Weisheng GuoDepartment of Minimally Invasive Interventional Radiology, The Second Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510260, China.ORCID https://orcid.org/0000-0002-8064-357X
Weiping WangState Key Laboratory of Pharmaceutical Biotechnology, Department of Pharmacology and Pharmacy, and Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Hong Kong, 999077, China.

Funding

Li Ka Shing Faculty of Medicine, University of Hong Kong start-up fundNational Natural Science Foundation of China 82372128National Natural Science Foundation of China U23A20489
6 · The paper itself

Abstract

Sunbathing excessively heightens the risk of skin carcinogenesis due to ultraviolet (UV)-mediated immunosuppression. Keratinocytes, the primary cells in epidermis, play a pivotal role in orchestrating the UV-induced immunosuppressive response by releasing platelet-activating factor (PAF) upon UV exposure. Adopting a paradigm shift that transforms a known health hazard as a potential therapeutic asset, a novel therapeutic strategy is set out to investigate for inflammatory conditions by leveraging immunosuppressive properties of UV-irradiated keratinocytes. To safely exploit this mechanism, extracellular vesicles are isolated from UV-irradiated keratinocytes, designate

Indexed as

Extracellular VesiclesImmunomodulationInflammatory Bowel DiseasesKeratinocytesPsoriasisUltraviolet RaysAnimalsDisease Models, AnimalHumansImiquimodMiceImiquimodextracellular vesicleimmunoregulatory nanomedicineinflammatory bowel diseasetolerogenic immunotherapy

Identifiers

PMID40605511
PMCPMC12462966

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.