Evidence map›Paper›PMID 40605436›Full record

ArticleJournal of Alzheimer's disease : JAD2025

Neighborhood deprivation and mortality among people with Alzheimer's disease and related dementia.

Joshua L Paley, Grant D Scheiffele, Yujia Li, C Elizabeth Shaaban, Yonghui Wu, Stephen Anton, Steven DeKosky, Jiang Bian, Jingchuan Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The social environment and cognitive aging over the life course: laying out critical concepts and research gaps.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joshua L PaleyDepartment of Health and Human Development, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-4484-5083
Grant D ScheiffeleDepartment of Pharmaceutical Outcomes and Policy, University of Florida, Gainesville, FL, USA.ORCID 0009-0006-7806-1446
Yujia LiDepartment of Pharmaceutical Outcomes and Policy, University of Florida, Gainesville, FL, USA.
C Elizabeth ShaabanDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-3016-1951
Yonghui WuDepartment of Health Outcomes and Biomedical Informatics, University of Florida, Gainesville, FL, USA.
Stephen AntonDepartment of Physiology and Aging, University of Florida, Gainesville, FL, USA.
Steven DeKoskyMcKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Jiang BianDepartment of Biostatistics and Health Data Science, Indiana University, Indianapolis, IN, USA.ORCID 0000-0002-2238-5429
Jingchuan GuoDepartment of Pharmaceutical Outcomes and Policy, University of Florida, Gainesville, FL, USA.

Funding

Research Education ComponentP30AG066468 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Julia K Kofler · 2020 to 2026
$29.4M
Computational Drug Repurposing for AD/ADRD with Integrative Analysis of Real World Data and Biomedical KnowledgeR01AG076234 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Jiang Bian, Fei Wang · 2022 to 2026
$3.8M
Eligibility criteria design for Alzheimer's trials with real-world data and explainable AIR01AG080991 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Jiang Bian, Fei Wang · 2023 to 2026
$3.1M
iSMART: intelligent Social risk Management in AD/ADRD paTientsR01AG089445 · NIA · UNIVERSITY OF FLORIDA · PI Jiang Bian, Jingchuan Guo · 2024 to 2026
$2.2M
Advancing Drug Repositioning for Alzheimer’s Disease using Real-world DataR56AG069880 · NIA · UNIVERSITY OF FLORIDA · PI BIAN, JIANG, CHEN, YONG · 2021 to 2022
$1.6M
Population neuroscience of sex differences in the Alzheimer's disease biomarker cascade: The role of cerebral small vessel diseaseK01AG071849 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI C. Elizabeth Shaaban · 2022 to 2026
$629k
NIA NIH HHS K01 AG071849NIA NIH HHS P30 AG066468NIA NIH HHS R01 AG076234NIA NIH HHS R01 AG080991NIA NIH HHS R01 AG089445NIA NIH HHS R56 AG069880
6 · The paper itself

Abstract

BackgroundThere are limited studies quantifying the extent to which neighborhood deprivation affects mortality in individuals living with Alzheimer's disease (AD) and AD-related dementias (AD/ADRD).ObjectiveTo quantify to what extent neighborhood deprivation affects adverse outcomes in individuals living with AD/ADRD.MethodsWe identified individuals with AD/ADRD using a 15% random sample of national Medicare fee-for-service beneficiaries. Area deprivation index (ADI) was spatially linked to the Medicare AD/ADRD cohort using zip codes. Multivariate logistic regression was applied to examine the association between ADI and all-cause mortality among beneficiaries with AD/ADRD.ResultsAfter adjusting for patients characteristics, compared to the lowest ADI quartile (Q1), higher ADI quartiles were associated with higher odds of all-cause mortality in individuals with AD/ADRD (Q2 = OR 1.08 [95% CI: 1.06, 1.10], Q3 = OR 1.09 [95% CI: 1.07, 1.11], and Q4 OR 1.05 [95% CI: 1.03, 1.07]).ConclusionsNeighborhood deprivation is an independent risk factor for mortality in persons with AD/ADRD.

Indexed as

Alzheimer DiseaseDementiaNeighborhood CharacteristicsResidence CharacteristicsAgedAged, 80 and overCohort StudiesFemaleHumansMaleMedicareMortalityRisk FactorsUnited StatesAlzheimer’s diseasearea deprivation indexmortalitysocial determinants of health

Identifiers

PMID40605436
PMCPMC12702488

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.