ArticleAdvanced healthcare materials2025
Ultra-Tiny Gelatin Nanoparticles-Assisted 3D Stem Cell Spheroids for Engineering Tissue Regeneration.
Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Short Segments of Electrospun Nanofibers Loaded with Curcumin Can Protect the Cells in Spheroids against Oxidative Stress.ACS applied nano materials · 2026Article
- Ultra-Tiny Gelatin Nanoparticles-Assisted 3D Stem Cell Spheroids for Engineering Tissue Regeneration.Advanced healthcare materials · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Stem cell spheroids offer an effective approach for tissue repair, disease modeling, and therapeutic applications. However, traditional spheroid cultures face certain limitations, such as uncontrolled cell proliferation and size, lack of structural complexity, and limited nutrient diffusion, eventually causing core apoptosis. Therefore, this study aims to propose an ultra-tiny gelatin nanoparticle (GNP)-assisted spheroid culture system designed to promote compact spheroid formation and enhance intra-/intercellular functionality. Highly biocompatible GNPs (80-150 nm) are fabricated with unique properties that promote cell-cell and cell-extracellular matrix (ECM) interactions, thereby enhancing functionality in stem cell spheroids. Compared to traditional stem cell spheroid culture methods, GNP-stem cell spheroids show improved cell viability, proliferation, and cellular complexity. Furthermore, the time-dependent regenerative potential of fabricated GNP-stem cell spheroids is investigated in hard and soft tissue defect sites. These findings indicate the significant role of GNP-stem cell spheroids in accelerating bone and skin tissue regeneration. These groundbreaking findings establish GNP-enhanced spheroids as a transformative innovation in regenerative medicine, surpassing traditional 3D stem cell therapies and advancing tissue engineering and biomedical research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.