ArticleClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Normal Soluble Fibrin Levels Suggest a Low Probability of Pulmonary Embolism in Patients with Deep Vein Thrombosis.
Article in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pulmonary embolism (PE) and deep vein thrombosis (DVT) are part of venous thromboembolism (VTE). Since PE can be fatal, early diagnosis in DVT patients is crucial. Diagnosing PE is often difficult due to non-specific symptoms. D-dimer testing is commonly used to exclude PE but is less effective in DVT patients because they generally have elevated D-dimer levels. Additionally, imaging, such as contrast-enhanced CT, may not be feasible for all patients. This study focused on soluble fibrin (SF), an early marker of thrombus formation that reflects thrombin generation, instead of D-dimer. Among 133 acute DVT patients who underwent imaging, 71 had PE (PE group), and 62 did not (no-PE group). All patients, except one patient in the no-PE group, exhibited elevated D-dimer levels, with no significant difference in the proportion of patients with normal D-dimer levels between the groups (
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