SynthesisOral diseases2025
Effect of Periodontal Treatment on Metabolic Syndrome Parameters: A Systematic Review.
Synthesis in Oral diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Metabolic Syndrome and Periodontitis-From Shared Mechanisms to Interdisciplinary Care: A Narrative Review of Clinical Evidence.Journal of clinical medicine · 2026Review
- Periodontitis and diabetes: a bidirectional link.Acta diabetologica · 2026Review
- Joint association of triglyceride glucose index (TyG) and body roundness index with the risk of periodontitis: a cross-sectional study.Frontiers in nutrition · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
aimTo evaluate the effects of periodontal treatment on metabolic syndrome (MS) parameters and systemic inflammatory biomarker levels in patients affected by both MS and periodontitis.
methodsA systematic search was conducted to identify randomized controlled trials (RCTs) with a follow-up ≥ 1 month comparing a more intense periodontal treatment (test intervention) to either a less intense or no periodontal treatment (control intervention). MS parameters such as triglycerides (TG), high-density lipoprotein cholesterol (HDL), fasting blood glucose (FBG), glycated hemoglobin (HbA1c), systolic blood pressure (SBP), diastolic blood pressure (DBP), waist circumference (WC), and systemic inflammatory biomarkers (i.e., C-reactive protein, CRP) were analyzed. Random-effects meta-regression analyses were conducted at 3- and 6-month follow-ups.
resultsFour RCTs were included. Test intervention resulted in a statistically significant greater SBP reduction at 3 (WMD 1.48) and 6 (WMD 1.88) months compared to control group. A statistically significant difference between groups was observed for FBG at 6 months after treatment, favoring test intervention (WMD 0.61). No differences were observed for the other MS parameters and for CRP at both 3- and 6-month follow-up.
conclusionsPeriodontal treatment seems to have beneficial effects on SBP and FBG in patients with MS and periodontitis at 3-6-month follow-ups.
trial registrationThis systematic review was registered under the protocol registration number CRD42024499854/PROSPERO.
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Registered trials
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