Evidence map›Paper›PMID 40605169›Full record

ArticleCombinatorial chemistry & high throughput screening2026

Improved Visualization Method of DNA Sequences and its Application in Phylogenetic Analysis.

Li Dong, Xinyang Jiang, Yong Liu, Yunlong Gao, Yan Yang

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Article in Combinatorial chemistry & high throughput screening, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Li DongThe College of Health Humanities, Jinzhou Medical University, Jinzhou 121001, China.
Xinyang JiangDepartment of Pediatrics, the Seventh Medical Center of Chinese PLA General Hospital, Beijing 100010, China.
Yong LiuDepartment of Orthopedics, Meihe Hospital of the First Hospital of Jilin University, Changchun 130000, China.
Yunlong GaoNewInsyght Biotech (Guangdong) Co., Ltd. DongGuan 523000, China.
Yan YangThe College of Health Humanities, Jinzhou Medical University, Jinzhou 121001, China.

Funding

Project of the Innovation Think Tank of the Liaoning Association for Science and Technology LNKX2025QN33
6 · The paper itself

Abstract

introductionWith a large number of species' genomes assembled, sequence comparison has become an effective method for further studying biological classification and evolution. Traditional sequence alignment relies on predefined scoring functions, but it is computationally intensive and lacks molecular justification for scoring the differences between sequences. Therefore, we have developed a graphical representation method for DNA sequences to facilitate better sequence comparison and evolutionary analysis.

methodIn this article, we introduce a novel method for representing DNA sequences using three-dimensional (3D) graphics. This method possesses two significant properties: (1) the graphical representation is acyclic; (2) each DNA sequence maintains a bijective relationship with its graphical representation.

resultLeveraging this proposed visualization method, we computed the corresponding ALE index for any DNA sequence by converting it into an L/L matrix and constructed a 12-dimensional feature vector. The feasibility of our proposed method has been validated through the construction of phylogenetic trees in four test sets: terrestrial vertebrates, hantavirus, fish and Japanese encephalitis virus. DISCUSSION: This method enables both quantitative analysis and visual comparison of DNA sequences, providing a versatile tool for evolutionary studies.

Indexed as

DNAPhylogenySequence Analysis, DNAAnimalsBase SequenceDNAALE-indexDNAL/L matrixnondegeneracyphylogenetic analysisvirus

Identifiers

PMID40605169

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.