Evidence map›Paper›PMID 40605166›Full record

ArticleCurrent medicinal chemistry2026

Synthesis and Biological Assessment of 3',4',5'-Trimethoxychalcone Derivatives against A549 and Molecular Insight Through Molecular Docking and Dynamics Studies.

Ade Danova, Piyanuch Wonganan, Panupong Mahalapbutr, Yusuf Eka Maulana, Elvira Hermawati, Didin Mujahidin, Warinthorn Chavasiri

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Article in Current medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ade DanovaOrganic Chemistry Division, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha 10, Bandung, West Java, 40132, Indonesia.ORCID 0000-0003-4716-1170
Piyanuch WongananDepartment of Pharmacology, Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand.
Panupong MahalapbutrDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Yusuf Eka MaulanaOrganic Chemistry Division, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha 10, Bandung, West Java, 40132, Indonesia.
Elvira HermawatiOrganic Chemistry Division, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha 10, Bandung, West Java, 40132, Indonesia.
Didin MujahidinOrganic Chemistry Division, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha 10, Bandung, West Java, 40132, Indonesia.
Warinthorn ChavasiriCenter of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn our previous work, 3',4',5'-Trimethoxychalcone with 3,4-disubstituent (OCH

methods3',4',5'-Trimethoxychalcone derivatives were prepared from 3',4',5'- trimethoxyacetophenone and substituted benzaldehyde using Claisen-Schmidt condensation under base condition. The pure products were characterized by

resultsNew compound (2) and sixteen known compounds (1, 3-17) were obtained. Compounds 6 and 7 were two of the best active compounds with IC

conclusionThe potential of 3',4',5'-trimethoxychalcone derivatives as anticancer agents for targeting A549 cancer cell lines warrants further investigation.

Indexed as

Antineoplastic AgentsChalconesMolecular Docking SimulationMolecular Dynamics SimulationProtein Kinase InhibitorsA549 CellsCell ProliferationDrug Screening Assays, AntitumorErbB ReceptorsHumansMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsChalconesEGFR protein, humanErbB ReceptorsProtein Kinase InhibitorsAnticancerEGFRmolecular dockingmolecular dynamicsstomach cancertrimethoxychalcones

Identifiers

PMID40605166

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.