ArticleMicrobiologyOpen2025
Optimization of Medium Composition for High Cell Density Culture of Bifidobacterium longum HSBL001 Using Response Surface Methodology.
Article in MicrobiologyOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Optimization of fermentation medium for advancing postbiotic antibacterial activity.AMB Express · 2026Article
- From genetic constraints to process hurdles: A review ofCurrent research in food science · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Bifidobacterium longum plays a critical role in the human gut and exhibits diverse probiotic functions. Achieving high-density fermentation of B. longum largely depends on the composition of the culture medium and fermentation conditions. This study aimed to optimize the medium composition and fermentation parameters for B. longum HSBL001, using viable cell counts and optical density at 600 nm (OD600) as indicators. The goal was to improve biomass yield and support the development and industrial application of highly active probiotic preparations. The optimal medium composition and culture conditions were established using a combination of single-factor experiments, the Plackett-Burman design, the steepest ascent method, and the central composite design. The optimized culture medium consisted of yeast extract (19.524 g/L), yeast peptone (25.85 g/L), arginine (0.599 g/L), glucose (27.36 g/L), MnSO
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Registered trials
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