Evidence map›Paper›PMID 40605132›Full record

ArticleJournal of the Chinese Medical Association : JCMA2025

Outcomes of postoperative preemptive sedation in the intensive care unit for geriatric patients with gastric cancer undergoing gastrectomy.

Wei-Ting Kuo, Chen-Yuan Hsiao, Shu-Cheng Chou, Ching-Shu Chiang, Tien-Hua Chen, Chi-Hung Lin, Pei-Jiun Tsai

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Article in Journal of the Chinese Medical Association : JCMA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Wei-Ting KuoInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
Chen-Yuan HsiaoDivision of Cardiovascular Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei, Taiwan, ROC.
Shu-Cheng ChouInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
Ching-Shu ChiangDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Tien-Hua ChenDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Chi-Hung LinInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
Pei-Jiun TsaiInstitute of Anatomy and Cell Biology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric cancer is a common malignancy worldwide, especially in East Asia. However, increasing age is an independent risk factor associated with high operative complications and surgical mortality in radical gastrectomy. To improve the prognosis of surgery, we proposed strategic postoperative sedation for geriatric patients with gastric cancer undergoing radical gastrectomy.

methodsA total of 324 gastric cancer patients, more than 75 years of age who underwent open radical gastrectomy at Taipei Veterans General Hospital between 2006 and 2020 were enrolled. The patients were classified into the sedation group (preemptive light sedation with prolonged mechanical ventilation assistance for the first five days postoperatively in the intensive care unit, n = 53) and the control group (early extubation, received morphine for pain control but no postoperative sedatives in the ordinary ward, n = 271). We compared the two groups' baseline clinical characteristics and the associated surgical outcome. We also conducted an in vitro cell experiment with RAW 264.7 macrophage cell line and evaluated the cell performance in various concentrations of sedation drug propofol and dexmedetomidine.

resultsPatients in the sedation group has significantly lower postoperative complication rates (13.7% vs 29.9%; p = 0.031). Among overall postoperative complications, the incidence rate of pulmonary events was significantly lower in the sedation group. Moreover, the incidence of other complications, including cardiac events, intra-abdominal abscesses, anastomotic leakage, adynamic ileus, and wound infection, was slightly higher in the matched control group without a statistically significant difference. Regarding surgical mortality rate and postoperative hospital length of stay (LOS), there were no significant differences between the two groups. For in vitro cell experiments with RAW 264.7 macrophage cell line, propofol, or dexmedetomidine significantly decreased tumor necrosis factor (TNF)-α production.

conclusionFor elderly patients with gastric cancer who undergo open radical gastrectomy, strategic postoperative sedation is safe and may reduce the incidence of pulmonary complications without prolonging hospital LOS.

Indexed as

GastrectomyHypnotics and SedativesIntensive Care UnitsStomach NeoplasmsAgedAged, 80 and overAnimalsDexmedetomidineFemaleHumansMaleMicePostoperative ComplicationsPropofolRAW 264.7 CellsDexmedetomidineHypnotics and SedativesPropofolGastrectomyGastric cancerIntensive care unitPostoperative preemptive sedationSurgical stress response

Identifiers

PMID40605132
PMCPMC12637121

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.