Evidence map›Paper›PMID 40605094›Full record

ArticleEuropean journal of medical research2025

Association between statins use and mortality in critically ill patients with sepsis included myocardial injury: a retrospective cohort study.

Shuxing Wei, Yiming Dong, Yanqian Su, Ying Chen, Xiya Wang, Hongmeng Dong, Danlei Weng, Yue Hu, Shubin Guo, Xue Mei and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shuxing Wei *Emergency Medicine Clinical Research Center, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, 100020, China.
Yiming Dong *Department of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, China.
Yanqian Su *Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, 100020, China.
Ying ChenEmergency Medicine Clinical Research Center, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, 100020, China.
Xiya WangEmergency Medicine Clinical Research Center, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, 100020, China.
Hongmeng DongEmergency Medicine Clinical Research Center, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, 100020, China.
Danlei WengEmergency Medicine Clinical Research Center, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, 100020, China.
Yue HuEmergency Medicine Clinical Research Center, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, 100020, China.
Shubin GuoEmergency Medicine Clinical Research Center, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, 100020, China. shubin007@yeah.net.
Xue MeiEmergency Medicine Clinical Research Center, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, 100020, China. meixue96@163.com.
Wenqing JiEmergency Medicine Clinical Research Center, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, 100020, China. jwq1224@126.com.

Funding

Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park Z211100002921061
6 · The paper itself

Abstract

backgroundThe treatment of patients with sepsis included myocardial injury (SIMI) remains a subject of debate. Given the pharmacological effects of statins in both sepsis and cardiovascular disease, this study aimed to investigate the association between statins use and the prognosis of SIMI.

methodsPatients with SIMI were primarily identified from the MIMIC-IV database. The patients were categorized into statins use and non-statins use groups, followed by propensity score matching (PSM) analysis to address baseline discrepancies between the groups. Univariate and multivariate Cox regression analyses were employed to assess the impact of statins on the prognosis of SIMI patients. The primary endpoint was 28-day all-cause mortality, with secondary outcomes including 90-day and 1-year all-cause mortality. To investigate whether the effects of certain factors vary across subgroups, subgroup analyse were performed.

resultsThe cohorts before and after PSM comprised 2550 and 1368 patients, respectively. In the PSM cohort, statins use was associated with a reduced 28-day all-cause mortality (hazard ratio [HR] = 0.65, 95% confidence interval [CI] 0.53-0.79, P < 0.001), 90-day all-cause mortality (HR = 0.65, 95% CI 0.54-0.77, P < 0.001), and 1-year all-cause mortality (HR = 0.72, 95% CI (0.53-0.79), P < 0.001). In addition, subgroup analyse suggested potential interactions between statins use and factors such as chronic kidney disease (CKD).

conclusionsStatins use is associated with a reduced short-term and long-term all-cause mortality rates in patients with SIMI.

Indexed as

Critical IllnessHydroxymethylglutaryl-CoA Reductase InhibitorsSepsisAgedFemaleHumansMaleMiddle AgedPrognosisPropensity ScoreRetrospective StudiesHydroxymethylglutaryl-CoA Reductase InhibitorsMortalitySepsis included myocardial injuryStatins

Identifiers

PMID40605094
PMCPMC12220614

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.