Evidence map›Paper›PMID 40605057›Full record

ArticleBMC chemistry2025

Development and validation of a LC-MS/MS method for the simultaneous determination of simnotrelvir and ritonavir in human serum and bronchoalveolar lavage fluid.

Xiaoyu Yang, Wanling Lin, Yushang Zhao, Chaoyue Zhao, Fei Zhou, Dong Wang, Zhihong Yue, Lin Pei, Mei Jia, Bin Cao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaoyu Yang *Department of Clinical Laboratory, Peking University People's Hospital, Xizhimen South Street No. 11, Beijing, 100044, China.
Wanling Lin *Department of Clinical Laboratory, Peking University People's Hospital, Xizhimen South Street No. 11, Beijing, 100044, China.
Yushang Zhao *Department of Clinical Laboratory, Peking University People's Hospital, Xizhimen South Street No. 11, Beijing, 100044, China.
Chaoyue ZhaoDepartment of Clinical Laboratory, Peking University People's Hospital, Xizhimen South Street No. 11, Beijing, 100044, China.
Fei ZhouState Key Laboratory of Respiratory Health and Multimorbidity, National Center for Respiratory Medicine, Beijing, China.
Dong WangSCIEX Analytical Instrument Trading Co, Shanghai, China.
Zhihong YueDepartment of Clinical Laboratory, Peking University People's Hospital, Xizhimen South Street No. 11, Beijing, 100044, China.
Lin PeiDepartment of Clinical Laboratory, Peking University People's Hospital, Xizhimen South Street No. 11, Beijing, 100044, China.
Mei JiaDepartment of Clinical Laboratory, Peking University People's Hospital, Xizhimen South Street No. 11, Beijing, 100044, China.
Bin CaoState Key Laboratory of Respiratory Health and Multimorbidity, National Center for Respiratory Medicine, Beijing, China.
Lin-Lin CaoDepartment of Clinical Laboratory, Peking University People's Hospital, Xizhimen South Street No. 11, Beijing, 100044, China. caoll@bjmu.edu.cn.
Hui WangDepartment of Clinical Laboratory, Peking University People's Hospital, Xizhimen South Street No. 11, Beijing, 100044, China. whuibj@163.com.

Funding

Peking University Medicine Fund of Fostering Young Scholars' Scientific & Technological Innovation BMU2024YFJHPY023Peking University People's Hospital Scientific Research Development Funds RDJP2022-57
6 · The paper itself

Abstract

"Xiannuoxin" (simnotrelvir/ritonavir) is a novel anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) drug developed in China, which plays an antiviral role by inhibiting 3C-like protease (3CL

Indexed as

Bronchoalveolar lavage fluidEpithelial lining fluidLC-MS/MSRitonavirSerumSimnotrelvirUrea

Identifiers

PMID40605057
PMCPMC12224748

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.