Development and validation of prognostic nomogram for overall survival in canine multicentric lymphoma: a retrospective study.

Zeyun Zhu, Zixiang Lin, Jun Dong, Di Zhang

Abstract readValidation Study

In one paragraph

Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Zeyun ZhuThe Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, China.

Zixiang LinThe Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, China.

Jun DongChina Agricultural University Veterinary Teaching Hospital, Beijing, China.

Di ZhangThe Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, China. dzhangdvm@cau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to develop and validate prognostic nomogram for predicting 3-month, 6-month, and 12-month overall survival in canine multicentric lymphoma. A total of 163 cases from January 2019 to December 2024 were used as a training set, and 50 cases from January 2017 to January 2019 served as a validation set. Predictors were identified using LASSO regression and univariate/multivariate Cox regression analyses, leading to the development of the nomogram: ATRAS2, incorporating age, red blood cell count at diagnosis, changes in red blood cell count after chemotherapy, and albumin-to-globulin ratio. Internal validation showed areas under the receiver operating characteristic curve for ATRAS2 of 0.991, 0.932, and 0.919 for 3-month, 6-month, and 1-year overall survival, respectively. Temporal validation yielded concordance indices of 0.708, 0.701 and 0.783 for 3-month, 6-month, and 1-year overall survival with calibration plots demonstrating strong agreement between predicted and observed overall survival. Decision curve analysis further confirmed the clinical utility of both models for 3-month, 6-month, and 12-month overall survival. The nomogram offers a tool for personalized survival evaluation of canine multicentric lymphoma.

Indexed as

Dog DiseasesLymphomaNomogramsAnimalsDogsFemaleMalePrognosisRetrospective StudiesCanine multicentric lymphomaOverall survivalPrognostic nomogramRetrospective study

Identifiers

PMID40604990

DOI10.1186/s12917-025-04857-y

PMCPMC12225038

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.