Evidence map›Paper›PMID 40604976›Full record

Observational studyRespiratory research2025

Childhood necrotising pneumonia, empyema and complicated parapneumonic effusion secondary to community acquired pneumonia: report of 158 cases from a tertiary hospital in Egypt.

Salma Abdelhady, Amira A Moharram, Zainab Fawzy, Eman Fouda

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Salma AbdelhadyDepartment of Paediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt. salmagamalhady@med.asu.edu.eg.
Amira A MoharramDepartment of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Zainab FawzyDepartment of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Eman FoudaDepartment of Paediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncidence of childhood complicated community acquired pneumonia (cCAP) is increasing worldwide. Necrotising pneumonia (NP), empyema and complicated parapneumonic effusion (CPPE) are the most common local complications.

methodsThis retrospective observational study describes clinical characteristics, aetiology and management of children hospitalized with cCAP in one of the largest tertiary centers in Egypt, over 5 years (December 2017 till September 2022).

resultsA total of 158 cases were identified. Seasonal variation was observed, as more cases were hospitalized during Winter and Spring. NP, empyema and CPPE, were diagnosed in 85 (54%), 52 (33%) and 21 (13%) children, respectively. 54 (64%) of children presented with NP had associated empyema or CPPE. The yield of pleural fluid, sputum and blood cultures were 23%, 18% and 17%, respectively. Community acquired MRSA was the predominant causative organism, followed by S pneumoniae. 87% of the patients had pleural interventions. 29 (18%) children received fibrinolytics. Three children presented with CAP and highly septated effusion, developed NP and persistent air leaks following fibrinolytic administration. Patients had prolonged hospitalization (median 17 days). 15 (10%) children had surgery. Children presented with NP had more morbidities and longer length of hospital stay, compared to children presented with CPPE and empyema. ICU admission, mechanical ventilation, severe anemia requiring blood transfusion, broncho-pleural fistula and surgical interventions were significantly higher in NP cohort. We report 5 mortalities, 4 of them below 1 year of age.

conclusionsThis study describes the largest cohort of children hospitalized with cCAP from Egypt till this date. Management of cCAP remains challenging worldwide and the current guidelines requires updating. Improvement of microbial detection and reporting is needed to promote antimicrobial stewardship.

Indexed as

Community-Acquired InfectionsEmpyemaEmpyema, PleuralPleural EffusionPneumonia, NecrotizingTertiary Care CentersAdolescentChildChild, PreschoolCommunity-Acquired PneumoniaEgyptFemaleHumansInfantMaleRetrospective StudiesChildrenCommunity acquired pneumoniaComplicated pneumoniaCOVID-19EmpyemaNecrotising pneumoniaNecrotizing pneumoniaParapneumonic effusionPleural effusionPleural fibrinolytics

Identifiers

PMID40604976
PMCPMC12224481

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.