Evidence map›Paper›PMID 40604972›Full record

ArticleRespiratory research2025

Spatial phenotyping of human bronchial airways in obstructive lung disease.

Latifa Khalfaoui, Raymond M Moore, Jose C Villasboas, Kaitlyn R Whitaker, Brenna C Novotny, Michael A Thompson, Christina M Pabelick, Y S Prakash

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Airway epithelial heterogeneity and mucus plugging in asthmatic bronchioles.American journal of respiratory and critical care medicine · 2026
    Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Latifa Khalfaoui *Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 4-184 W Jos SMH, 200 First St SW, Rochester, Minnesota, 55905, USA.
Raymond M Moore *Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Jose C VillasboasDivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Kaitlyn R WhitakerDivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Brenna C NovotnyDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Michael A ThompsonDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, 4-184 W Jos SMH, 200 First St SW, Rochester, Minnesota, 55905, USA.
Christina M PabelickDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, 4-184 W Jos SMH, 200 First St SW, Rochester, Minnesota, 55905, USA.
Y S PrakashDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, 4-184 W Jos SMH, 200 First St SW, Rochester, Minnesota, 55905, USA. Prakash.ys@mayo.edu.

Funding

Hydrogen Sulfide in Neonatal Airway DiseaseR01HL160570 · NHLBI · MAYO CLINIC ROCHESTER · PI Christina Maria Pabelick, Y. S. Prakash · 2023 to 2026
$2.4M
Mayo Clinic Immune Monitoring CoreNHLBI NIH HHS R01 HL160570NIH HHS R01 HL160570
6 · The paper itself

Abstract

Chronic respiratory diseases such as asthma and COPD involve interactions between multiple resident and immune cell types within bronchial airways, resulting in structural and functional changes. Thus cellular heterogeneity, arrangements and associated neighborhoods as well as interactions between cells and matrices represent intriguing yet challenging areas of study. Spatial phenotypic profiling facilitates exploration of these issues of the cellular microenvironment and identification of context-dependent cell-cell interactions. Utilizing spatial phenotyping, we interrogated the features and cellular landscape of lungs from non-asthmatics, asthmatics, and COPD in FFPE samples by developing a 10-plex antibody panel for the Akoya PhenoCycler

Indexed as

AsthmaBronchiPulmonary Disease, Chronic ObstructiveAdultAgedFemaleHumansMaleMiddle AgedPhenotypeAirway epitheliumAsthmaCell-cell interactionsCell-matrix interactionsCODEXCOPDFunctional phenotypingImmune cellMesenchymeNeighborhoodsSpatial biology

Identifiers

PMID40604972
PMCPMC12224523

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.