ArticleBMC oral health2025
Qualitative radiographic characteristics of MRONJ-affected bone in oral and parenteral drug administration: comparison of panoramic radiography and cone-beam CT.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Deep learning-based automatic segmentation of MRONJ lesions on CBCT images.BMC oral health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOur aim was to compare the capacity of panoramic radiography (PR) and cone-beam computed tomography (CBCT) first for the detection of bone affected by medication-related osteonecrosis of the jaw (MRONJ) using qualitative radiographic parameters; and second for the evaluation of the relationship between drug administration route and associated bone changes.
methodsPR and CBCT images of 24 MRONJ patients using oral or intravenous (IV) bisphosphonates were scored for the detection of osteolysis, osteosclerosis, lamina dura thickening, periodontal ligament widening, persistent extraction socket, sequestration, periosteal new bone formation, narrowing of the inferior alveolar canal, pathologic fracture, and cortical bone erosion. Fisher’s Exact and independent samples t-tests were used for comparisons (p = 0.05).
resultsThe most frequent parameters observed in PR of all patients were osteosclerosis, osteolysis and cortical bone erosion, respectively. The equivalent rank in CBCT was cortical bone erosion, osteosclerosis and osteolysis. CBCT showed better diagnostic performance for the detection of periosteal new bone formation and cortical bone erosion in both oral and IV bisphosphonate groups (p < 0.05). No difference was obtained between the diagnostic performances of two imaging methods for the discrimination of the remaining parameters (p > 0.05). A higher number of radiographic markers were detected in both PR and CBCT images of patients using IV bisphosphonates (p > 0.05).
conclusionIn this study, the diagnostic performance of PR was comparable to CBCT for the detection of most of the qualitative radiographic markers of MRONJ-affected bone in patients using oral and IV bisphosphonates. However, CBCT may be preferred for the diagnosis of periosteal new bone formation, cortical bone erosion, and pathologic fracture.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.