SynthesisBMC palliative care2025
Immunosuppressant management in palliative care: a systematic review.
Synthesis in BMC palliative care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo summarize the available literature on the management of immunosuppressive therapy in palliative care patients at the end-of-life stage, highlighting challenges associated with decision-making in this context and the current lack of clear clinical guidelines.
methodsA systematic search was conducted in the PubMed, EMBASE, and Medline databases for studies evaluating the application of immunosuppressive therapy in patients nearing the end of life or patients who have allograft failure without plans for retransplantation and thus are candidates for palliative care. The search strategy followed PRISMA guidelines.
resultsWe screened 2892 studies, assessed 23 records for eligibility, and included 9 publications in the systematic review. These studies cover different immunosuppressive strategies in palliative care for patients with solid organ or stem cell transplants. The evidence suggests that it is common practice to discontinue immunosuppression for patients with allograft failure who do not have any plans for retransplantation. Corticosteroids can be used to ameliorate the negative effects that arise from immunosuppressant discontinuation.
conclusionsThe management of immunosuppression after allograft failure requires a careful balance between minimizing drug-related risks and preserving future transplant eligibility. Discontinuing immunosuppression may be appropriate for many patients nearing the end of life, provided that symptom management and ethical considerations are prioritized. Standardized guidelines and multidisciplinary approaches are needed to optimize immunosuppression withdrawal, reduce complications, and ensure patient-centered care.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.