Trial reportBMC oral health2025
Platelet-rich fibrin versus acellular dermal matrix for vertical soft tissue augmentation simultaneously with dental implantation: a 3-month randomized pilot clinical trial.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Use of cells and/or biologics combined with scaffolds for soft tissue regeneration around dental implants.Journal of periodontology · 2026Pooled it
- New technologies in oral reconstructive medicine: Consensus report of the AAP/OF/SEPA Workshop.Journal of periodontology · 2026Article
- Recent Advances in Regenerative Therapies in Periodontology.Dentistry journal · 2025Review
- Volumetric changes associated with immediate implant placement and Bio-Oss collagen.Bioinformation · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVertical soft tissue thickness is critical for peri-implant health and aesthetics. Platelet-rich fibrin (PRF) and acellular dermal matrix (ADM) are increasingly used for soft tissue augmentation during dental implantation, but direct comparisons of their efficacy are limited. This study aimed to compare the efficacy of PRF and ADM for vertical soft tissue augmentation, simultaneously with dental implantation.
methodsThis pilot randomized controlled clinical trial included 20 patients with thin soft tissue phenotypes (≤ 2 mm) in the posterior mandible. Patients were randomly assigned to the PRF (n = 10) or ADM (n = 10) groups. The primary outcome was gingival thickness measured at baseline and three months postoperatively via a #15 endodontic file and a digital caliper. The Shapiro-Wilk test was used to assess data normality. Data were analyzed via independent and paired t-tests for normally distributed data and Mann-Whitney and Wilcoxon tests for non-normally distributed data. Chi-square tests and Fisher's exact tests used to compare sex distribution between groups. Between-group comparisons at baseline and three months were performed, with significance set at P < 0.05.
resultsThe baseline gingival thickness did not differ significantly between the groups (P = 0.19). At three months, gingival thickness significantly increased in both the PRF (from 1.66 ± 0.23 mm to 3.30 ± 0.75 mm) and ADM (from 1.52 ± 0.22 mm to 2.58 ± 0.47 mm) groups (P < 0.001 for both). Although the gingival thickness at three months was significantly greater in the PRF group (p = 0.02), the mean soft tissue gain was not significantly different between the groups (P = 0.081).
conclusionsBoth PRF and ADM significantly increased gingival thickness three months post-surgery, with PRF resulting in greater overall thickness. These preliminary findings support using PRF and ADM as effective options for vertical soft tissue augmentation during dental implantation. However, given the pilot nature of this study, further research with larger sample sizes and longer follow-up periods is needed to validate these results.
trial registrationThis project was registered in the Iranian Registry of Clinical Trials under the ID (IRCT20200914048713N1) and registration date 30/11/2021.
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