ArticleRespiratory research2025
X-ray velocimetry provides temporally and spatially-resolved biomarkers of lung ventilation in small airways disease.
Article in Respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04489758 (Utility of a Novel Imaging Algorithm), which is not on this map. Cited by 2 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Utility of a Novel Imaging Algorithm (4DX) for the Diagnosis of Constrictive Bronchiolitis
Who cites it
2 citing papers in PubMed.
- Murine Functional Lung Imaging Using X-Ray Velocimetry for Longitudinal Noninvasive Quantitative Spatial Assessment of Pulmonary Airflow.Tomography (Ann Arbor, Mich.) · 2025Article
- Hyperconcentrated mucus in small airways: a mechanistic model for the pathogenesis of paediatric bronchiectasis.European respiratory review : an official journal of the European Respiratory Society · 2025Review
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Authors and funding
11 authors.
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Abstract
backgroundSmall airways disease is a feature of many respiratory conditions. Currently available methods of diagnosing small airways lack sensitivity and/or cannot evaluate spatial heterogeneity. New diagnostic strategies for diagnosing small airways disease are needed.
methodsWe determined the regional displacement of lung tissue calculated from fluoroscopic lung images acquired at multiple angles over sequential time points as a surrogate of ventilation. We applied this technique, which we call X-ray velocimetry (XV), to patients with chronic obstructive pulmonary disease (COPD) and impaired spirometry and veterans with deployment-related constrictive bronchiolitis (DR-CB) but preserved spirometry to determine XV-derived biomarkers specific for each condition.
resultsWe identified disease- and stage-specific XV biomarkers for COPD patients that correlated with airflow obstruction on spirometry. Further, we identified a set of XV-derived biomarkers that could distinguish veterans with DR-CB from controls despite normal spirometry in most patients from both groups.
conclusionsXV may provide a safe and widely-available strategy for diagnosing small airways disease while preserving spatial information. Future studies are required to validate the biomarkers described here in larger patient cohorts.
trial registrationNot required for this study. However, participants enrolled at VUMC were enrolled under ClinicalTrials.gov study NCT04489758 (submitted 07/23/2020).
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