Trial reportBMC oral health2025
Effect of different administration methods of dexamethasone on postoperative pain and swelling following implant flap surgery: A randomized controlled trial of patient-centered outcomes.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundTooth implant treatment is frequently accompanied by postoperative pain and swelling. While dexamethasone is known to mitigate these symptoms, the optimal administration method remains unclear. This study compared the effects of different administration methods of dexamethasone on alleviating pain and swelling after flap implantation surgery.
methodsPatients with dentition defects requiring implant treatment were grouped according to whether dexamethasone was administered via submucosal injection during the surgery or orally after the surgery. Pain and swelling levels were measured and recorded within 72 h post-operation, along with potential influencing factors including gender, age, number of implants, duration of surgery, oral hygiene status, preoperative anxiety level, and pain sensitivity score using Pain Sensitivity Questionnaire (PSQ). The differences in pain and swelling between the two groups at different time points were compared, and Pearson correlation and multiple linear regression analyses were conducted on the potential influencing factors.
resultsWhile pain and swelling scores in the submucosal injection group were consistently lower than in the oral group at all time points, these intergroup differences did not reach statistical significance (P > 0.05). However, significant time effects were observed within each group (P < 0.05), with swelling reduction occurring earlier in the submucosal injection group (24 h vs 48 h). Correlation and regression analyses showed that higher scores in PSQ-total and preoperative anxiety level, as well as a greater number of implants, were associated with higher pain levels, while postoperative swelling was significantly greater in females than in males.
conclusionsIntraoperative submucosal dexamethasone was associated with earlier swelling reduction compared to oral administration, though both methods showed comparable pain control. These findings suggest a potential clinical advantage for the intraoperative route that warrants further investigation.
trial registrationThis study was registered on Chinese Clinical Trial Registry, and the trial registration number is ChiCTR2500098816. Registered March 13, 2025- Retrospectively registered, https://www.chictr.org.cn/bin/project/edit?pid=257854 .
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.