ArticleBMC public health2025
Global, regional, and national trends in the epidemiology of aortic aneurysms among women of childbearing age, 1990-2021, with predictions through 2036.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Global, Regional, and Future Predictions of Cardiovascular Disease Burden Among Women of Childbearing Age: A Systematic Analysis of the Global Burden of Disease Study 1990-2021.International journal of women's health · 2026Article
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5 authors.
Funding
Abstract
backgroundAortic aneurysms (AA) pose a significant risk to women of childbearing age due to the added physiological stress of pregnancy and hormonal changes. This study aims to assess the global disease burden of AA among women of childbearing age from 1990 to 2021, project future trends, and provide evidence-based insights to inform public health policies and clinical decision-making.
methodsAortic aneurysm mortality and disability-adjusted life years (DALYs) data for women of childbearing age (15-49 years) from 1990 to 2021 were extracted from the 2021 Global Burden of Disease (GBD) dataset. Temporal trends and attributable risks were evaluated using estimated annual percentage change (EAPC) and linear regression model from 1990 to 2021. Cluster analysis identified patterns across GBD regions. The Socio-demographic Index (SDI) assessed regional and national differences in mortality and DALYs rates related to AA. In addition, all potential risk determinants associated with AA were systematically examined. An age-period-cohort model assessed trends, period, and cohort effects, while the Bayesian age-period-cohort model predicted the disease burden through 2036.
resultsIn 2021, AA was associated with 2,552 (95% UI: 2,273 to 2,827) mortality and 86,466 (95% UI: 72,510 to 115,049) DALYs counts worldwide among women of childbearing age. The age-standardized mortality rate (ASMR) and age-standardized DALYs rate for AA decreased from 1.58 (95% UI: 1.41 to 1.76) to 1.28 (95% UI: 1.10 to 1.42), and from 28.52 (95% UI: 25.56 to 32.53) to 23.01 (95% UI: 20.49 to 25.27), respectively, between 1990 and 2021. By SDI quintile, the EAPC for both mortality and DALYs increased in the low-middle and middle SDI regions. Using the average age, period, and cohort as reference groups, the risk of AA death increased with age [RR
conclusionsAlthough the global burden of AA among women of childbearing age is decreasing, significant regional disparities persist, and the rising prevalence of hypertension and high BMI poses ongoing challenges. Strengthened prevention strategies targeting modifiable risk factors are urgently needed to further reduce disease burden and promote health equity.
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