Evidence map›Paper›PMID 40604719›Full record

SynthesisBMC public health2025

The association between occupational silica exposure and leukemia: a systematic review and meta-analysis of cohort studies.

Jiyuan Shao, Shengchun Wang, Hong Cheng, Pengfei Fu, Xin Zhang

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jiyuan ShaoInstitute of Environmental Science, Shanxi University, Taiyuan, China.
Shengchun WangInstitute of Environmental Science, Shanxi University, Taiyuan, China.
Hong ChengInstitute of Environmental Science, Shanxi University, Taiyuan, China.
Pengfei FuFaculty of Health, York University, Toronto, ON, Canada. fredpfu@yorku.ca.ORCID http://orcid.org/0000-0003-0560-0550
Xin ZhangInstitute of Environmental Science, Shanxi University, Taiyuan, China. xinzhang0051@sxu.edu.cn.

Funding

National Natural Science Foundation of China 42177419
6 · The paper itself

Abstract

Respirable crystalline silica is a proven lung carcinogen, but there is limited information of the carcinogenic effects of silica on non-respiratory organs. We aimed to systematically review cohort studies and conduct a meta-analysis to explore the relationship between occupational exposure to silica and the risk of leukemia development. We performed an exhaustive search across three databases (PubMed, Embase, and Web of Science) to identify pertinent cohort studies published since 1987. After removing duplicates and excluding irrelevant studies, 22 studies were included in our analysis. We utilized fixed-effects models in the implementation of our meta-analysis. The combined relative risk of leukemia associated with occupational silica exposure was determined to be 1.11 (95% CI: 0.93-1.33), with no significant differences observed across various industries, geographic regions, exposure periods, or study quality estimates. The present study based on cohort studies provide no evidence that occupational exposure to silica does increase the risk of leukemia.

Indexed as

LeukemiaOccupational DiseasesOccupational ExposureSilicon DioxideCohort StudiesHumansSilicon DioxideLeukemiaMeta-analysisOccupational exposureSilica

Identifiers

PMID40604719
PMCPMC12220357

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.