ArticleBMC complementary medicine and therapies2025
The anticancer potential of Origanum onites L. in gastric cancer through epigenetic alterations.
Article in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Essential Oils as a Source of Anticancer Molecules: Critical Assessment of Current Evidence and Methodological Limitations-A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Natural Plant Bioactives as Regulators of Histone Modifications: Bridging Epigenetics and Anticancer Therapy.Phytotherapy research : PTR · 2026Review
- The interplay of the microbiome, host genetics, and epigenetic modifications in gastric cancer.Frontiers in microbiology · 2026Review
- Targeted phytotherapy: essential oils, multi-target cancer action & nanodelivery.Frontiers in oncology · 2026Review
- Advances in epigenetics of gastric cancer.Oncology reviews · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundEpigenetic alterations are crucial in gastric cancer (GC) development and progression. As these modifications are reversible, targeting them may offer preventive and therapeutic benefits. Origanum onites L. essential oil (OOEO) has demonstrated anticancer properties in various cancers, but its epigenetic effects in GC remain unexplored.
methodsOOEO was extracted by water distillation, and its effects on gastric adenocarcinoma (AGS) and normal gastric epithelial (GES-1) cells were evaluated. Cytotoxicity was assessed via WST-8 assay, apoptosis by Annexin V staining, DNA damage by γ-H2AX test, and epigenetic modifications by methylation-specific PCR and histone modification analysis.
resultsCompared to GES-1 cells, OOEO exhibited cytotoxic activity even at lower concentrations in AGS cells. OOEO treatment induced apoptosis and DNA double-strand breaks and arrested cell cycle at S and G
conclusionOOEO exhibits epigenetic regulatory properties that may contribute to GC prevention and treatment. Its potential in neoadjuvant or combinatory therapies warrants further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.