SynthesisBMC oral health2025
Regenerative potential of human dental pulp stem cells in scaffold-based alveolar and jaw bone reconstruction: a systematic review.
Synthesis in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Comparative Analysis of Stemness and Differentiation Gene Expression in Mesenchymal Stem Cells from Permanent and Deciduous Teeth: An In Vitro Study to Evaluate Implications for Regenerative Dentistry.Biochemical genetics · 2026Article
- New technologies in oral reconstructive medicine: Consensus report of the AAP/OF/SEPA Workshop.Journal of periodontology · 2026Article
- Effect of hUCMSC-seeded hydroxyapatite-chitosan scaffolds on immunomodulatory cytokine expression during alveolar socket healing: an in vivo study.Odontology · 2026Article
- The key role of RANKL and OPG as molecular biomarkers in bone remodeling associated with different grafts regarding socket preservation: A systematic review.Journal of Taibah University Medical Sciences · 2026Review
- Alveolar socket preservation with human umbilical cord mesenchymal stem cell-seeded hydroxyapatite-chitosan scaffolds: An in vivo assessment of osteoprotegerin and receptor activator of nuclear factor-κB expression.Journal of molecular histology · 2026Article
- Apple-Derived Vesicles Orchestrate Bone Regeneration:International journal of molecular sciences · 2026Article
- Research on Injectable Hydrogel GelMA-HA-CGF Loaded with Dental Pulp Stem Cells (DPSC) for Periodontal Regeneration.ACS omega · 2026Article
- Dental pulp stem cells and hydroxyapatite: a promising combination for maxillary bone regeneration.BMC oral health · 2026Article
- Stem cell-based scaffolds using dental pulp and adipose-derived stem cells in periodontal regeneration: Evidence from preclinical or clinical studies.Bioinformation · 2026Article
- Can Mesenchymal Stem Cells Improve Bone Regeneration in Maxillary Sinus Augmentation? A Systematic Review and Meta-Analysis.Stem cells international · 2026Review
- Antibiotic approaches to endodontic regeneration.Biomaterial investigations in dentistry · 2026Review
- Effects of Caffeine on Dental Mesenchymal Stem Cells: Implications for Regenerative Applications.Journal of functional biomaterials · 2025Article
- The Analgesic Effect of NLRP3 Inflammasome in the Relief of Inflammatory Pain by Electroacupuncture: A Systematic Review and Meta-Analysis of Animal Studies.Journal of pain research · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEffective alveolar and jaw bone regeneration remains a clinical challenge, and the added value of incorporating human dental pulp stem cells (hDPSCs) or stem cells from exfoliated deciduous teeth (SHED) into scaffolds over traditional cell-free approaches has not been systematically evaluated in vivo, limiting evidence-based advancements in regenerative dental therapies. This review aimed to evaluate the outcomes of human dental pulp stem cells in conjunction with scaffolds for the regeneration of alveolar and jaw bone. MATERIALS AND
methodsThis systematic review followed PRISMA guidelines and used the PICO framework. A comprehensive search was conducted in PubMed, Scopus, Embase, Web of Science, the Cochrane Library, and Google Scholar through April 2025, focusing on studies using human dental pulp stem cells and scaffolds for alveolar and jaw bone regeneration in animal models. Inclusion criteria were restricted to English-language in vivo trials that compared cell-free scaffolds with those incorporating hDPSCs or SHED in conjunction with scaffolds. Risk of bias was assessed with a modified CAMARADES tool. The review is registered with PROSPERO (CRD420250655330).
resultsNineteen studies fulfilled the inclusion criteria. Among these, 8 studies concentrated on bone regeneration using SHED, while 11 investigated DPSCs obtained from permanent teeth. The findings revealed that scaffolds seeded with DPSCs achieved new bone formation rates ranging from 0.2 to 70.5%, whereas scaffolds seeded with SHED exhibited 32.64% and 40% regeneration rates.
conclusionsIntegrating human DPSCs or SHED with scaffolds consistently improves alveolar and jaw bone regeneration over scaffold-only approaches, enhancing bone volume, density, osteogenesis, and angiogenesis and showing strong potential for future clinical use. CLINICAL TRIAL NUMBER: Not applicable.
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