Evidence map›Paper›PMID 40604659›Full record

Trial reportBMC oral health2025

Treatment outcomes of pulpotomy in primary molars utilizing 2.25% sodium hypochlorite gel: a randomized controlled trial.

Mawia Karkoutly, Amirah Alnour, Amjad Abu Hasna, Ok Hyung Nam, Saleh Al Kurdi, Nada Bshara

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mawia KarkoutlyDepartment of Pediatric Dentistry, Faculty of Dentistry, Damascus University, Damascus, Syrian Arab Republic. mawia95.karkoutly@damascusuniversity.edu.sy.
Amirah AlnourDepartment of Oral and Maxillofacial Pathology, Faculty of Dentistry, Damascus University, Damascus, Syrian Arab Republic.
Amjad Abu HasnaDepartment of Restorative Dentistry, Endodontics Division, Institute of Science and Technology (UNESP), São Paulo State University, São José Dos Campos, Brazil.
Ok Hyung NamDepartment of Pediatric Dentistry, School of Dentistry, Kyung Hee University, Seoul, Korea.
Saleh Al KurdiDepartment of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Arab International University, Daraa, Syrian Arab Republic.
Nada BsharaDepartment of Pediatric Dentistry, Faculty of Dentistry, Damascus University, Damascus, Syrian Arab Republic.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSodium hypochlorite (NaOCl) gel can be a potential substitute in daily pediatric dentistry practice. Given its high antimicrobial efficacy, NaOCl gel is expected to induce healing and improve pulpotomy treatment outcomes. This study aimed to perform a histological, clinical, and radiographical evaluation of pulpotomy in human primary molars utilizing 2.25% (NaOCl) gel as a medicament, followed by white mineral trioxide aggregate (WMTA) as a base material. MATERIALS AND

methodsA randomized, second-blinded, split-mouth clinical trial was conducted in cooperative patients aged 8-10 years with 48 carious first primary molars, which were treated by: (I) NaOCl gel group: following hemostasis, teeth were pulpotomized utilizing 2.25% NaOCl gel, and then WMTA paste was applied as a dressing material, and (II) control group: following hemostasis, WMTA paste was applied as a dressing material. Later, each group was sub-divided into three sub-groups (n = 8) according to the time planned for serial extraction: (I) 7 days, (II) 30 days, and (III) 90 days for histological evaluation. In addition, 40 s primary molars in cooperative patients aged 5-10 years indicated for pulpotomy were randomly allocated into two groups for clinical and radiographical evaluation at 3, 6, and 12 months follow-up. Data were analyzed by applying the chi-square test (p < 0.05).

resultsNaOCl gel improved odontoblastic integrity and dentin bridge formation (p < 0.001) without increasing pulp necrosis or calcifications. The NaOCl gel group showed a 90% clinical and radiographical success rate at 3, 6, and 12 months of follow-up. In the control group, the clinical success rate was 85% after 3, 6, and 12 months, whereas the radiographical success rate was 100% at 3 months and decreased to 85% after 6 and 12 months.

conclusionsUtilizing 2.25% NaOCl gel as a medicament in human primary molars pulpotomy improved the treatment outcomes of the WMTA.

trial registrationISRCTN registry, ISRCTN15908457, registered 22 July 2024.

Indexed as

MolarPulpotomySodium HypochloriteTooth, DeciduousAluminum CompoundsCalcium CompoundsChildDental CariesDrug CombinationsFemaleGelsHumansMaleOxidesSilicatesTreatment OutcomeAluminum CompoundsCalcium CompoundsDrug CombinationsGelsmineral trioxide aggregateOxidesSilicatesSodium HypochloriteMineral trioxide aggregateMolarPrimary teethPulpotomySodium hypochlorite

Identifiers

PMID40604659
PMCPMC12224463

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.