Evidence map›Paper›PMID 40604653›Full record

ArticleBMC oral health2025

Nuclear factor I-C regulates enamel and dentin formation via the Sonic hedgehog signaling pathway in mouse incisors.

Rui Zhang, Ruiqi Li, Xiaofeng Huang

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Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rui ZhangDepartment of Stomatology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong'an Road, Xicheng District, Beijing, 100050, China.
Ruiqi LiDepartment of Stomatology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong'an Road, Xicheng District, Beijing, 100050, China.
Xiaofeng HuangDepartment of Stomatology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong'an Road, Xicheng District, Beijing, 100050, China. huangxf1998@163.com.

Funding

Beijing Natural Science Foundation 7252026the National Natural Science Foundation of China 82071141
6 · The paper itself

Abstract

backgroundTooth development involves interactions between epithelium and mesenchyme conducted via multiple signaling molecules. This study aimed to investigate the roles of Nuclear factor I-C (NFIC) and Sonic hedgehog (SHH) in regulating enamel and dentin formation in mouse incisors.

methodsNfic gene knockout (Nfic

resultsAfter PN3.5, mandibular incisor volumes were smaller in Nfic

conclusionEnamel and dentin formation in mouse incisors is regulated by NFIC via SHH as a downstream target.

Indexed as

Dental EnamelDentinDentinogenesisHedgehog ProteinsIncisorNFI Transcription FactorsSignal TransductionAmelogeninAnimalsDentin SialophosphoproteinExtracellular Matrix ProteinsMiceMice, KnockoutOdontogenesisPhosphoproteinsSialoglycoproteinsAmelogeninDentin SialophosphoproteinExtracellular Matrix ProteinsHedgehog ProteinsNFI Transcription FactorsPhosphoproteinsShh protein, mouseSialoglycoproteinsDentin formationEnamelIncisorNFICSHHTooth development

Identifiers

PMID40604653
PMCPMC12224396

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.