Evidence map›Paper›PMID 40604648›Full record

ArticleBMC pregnancy and childbirth2025

A surveillance-based epidemiological study of renal agenesis in 25 million births in china, 2007-2020.

Yuyang Gao, Wenli Xu, Wenyan Li, Zhiyu Chen, Qi Li, Zhen Liu, Li Dai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuyang GaoNational Center for Birth Defects Monitoring, West China Second University Hospital, Sichuan University, No.17 Section 3 Renminnanlu, Chengdu, Sichuan, 610041, China.
Wenli XuNational Center for Birth Defects Monitoring, West China Second University Hospital, Sichuan University, No.17 Section 3 Renminnanlu, Chengdu, Sichuan, 610041, China.
Wenyan LiNational Center for Birth Defects Monitoring, West China Second University Hospital, Sichuan University, No.17 Section 3 Renminnanlu, Chengdu, Sichuan, 610041, China.
Zhiyu ChenNational Center for Birth Defects Monitoring, West China Second University Hospital, Sichuan University, No.17 Section 3 Renminnanlu, Chengdu, Sichuan, 610041, China.
Qi LiNational Center for Birth Defects Monitoring, West China Second University Hospital, Sichuan University, No.17 Section 3 Renminnanlu, Chengdu, Sichuan, 610041, China.
Zhen LiuNational Center for Birth Defects Monitoring, West China Second University Hospital, Sichuan University, No.17 Section 3 Renminnanlu, Chengdu, Sichuan, 610041, China.
Li DaiNational Center for Birth Defects Monitoring, West China Second University Hospital, Sichuan University, No.17 Section 3 Renminnanlu, Chengdu, Sichuan, 610041, China. daili@scu.edu.cn.

Funding

National Key Research and Development Program of China 2017YFC0907304
6 · The paper itself

Abstract

backgroundRenal agenesis (RA), a rare congenital kidney defect, varies in clinical severity. Unilateral renal agenesis (URA) is more prevalent and may cause long-term renal complications, whereas bilateral renal agenesis (BRA) is typically fatal. While epidemiological data on RA is limited in China, understanding its prevalence and associated factors is crucial for public health interventions.

methodsWe conducted a prevalence analysis using data from the Chinese Birth Defects Monitoring Network between 2007 and 2020. Prevalence rates of RA, URA, and BRA were calculated and stratified by birth year, maternal age, residence area, geographical region, and infant sex. Temporal trends in prevalence were examined. We also investigated pregnancy outcomes among affected infants, including preterm births, low birth weight, early neonatal deaths, and termination of pregnancy for fetal anomaly (TOPFA). Furthermore, co-occurring congenital anomalies were assessed. Poisson regression analysis was used to assess the distribution of URA and BRA across residential areas and geographic regions and to identify factors associated with their prevalence.

resultsAmong 25,909,000 births between 2007 and 2020, a total of 5,906 cases of RA were identified (5,020 URA and 780 BRA). The prevalence rates per 10,000 live and still births were 2.28 for RA, 1.94 for URA, and 0.30 for BRA, all showing an increasing trend over the study period. Compared to URA, BRA was significantly associated with a higher proportion of preterm birth, low birth weight, early neonatal death, and TOPFA. Poisson regression analysis revealed a consistent distribution of URA and BRA across residential areas and geographic regions, with higher prevalence observed in urban areas and the eastern and central regions of China. Maternal age < 35 years and female sex were associated with a higher prevalence of URA, while male sex was associated with a higher prevalence of BRA. Both URA and BRA frequently co-occurred with congenital malformations of the circulatory, urinary, and musculoskeletal systems.

conclusionsThe study provides the first comprehensive epidemiological assessment of RA in China. The increasing prevalence and distinct differences in the pregnancy outcomes between URA and BRA underscore the importance of timely prenatal diagnosis and appropriate counseling for affected families.

Indexed as

Congenital AbnormalitiesKidneyKidney DiseasesAdultChinaEpidemiological MonitoringFemaleHumansInfant, NewbornMalePregnancyPregnancy OutcomePremature BirthPrevalenceYoung AdultChineseEpidemiologyPrevalence rateRenal agenesis

Identifiers

PMID40604648
PMCPMC12225177

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.