ArticleBMC pregnancy and childbirth2025
Maternal red blood cell folate and vitamin B metabolism with pregnancy outcomes: a retrospective study.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Awareness and Use of Folic Acid Among Pregnant Women in Western Ukraine: A Pilot Study.International journal of environmental research and public health · 2026Article
- Association between erythrocyte folate and pregnancy: A scientometric analysis.Pakistan journal of medical sciences · 2025Review
- Folic Acid Ameliorates the Chronic Constriction Injury of Sciatic Nerve -Induced Memory Impairments in Rats.Iranian journal of pharmaceutical research : IJPRArticle
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Authors and funding
4 authors.
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Abstract
backgroundVitamin B plays a crucial role in pregnancy, influencing maternal and fetal health. However, the impact of Vitamin B metabolism alterations on pregnancy outcomes remains unclear. This study investigates the association between Vitamin B metabolism and adverse pregnancy outcomes (APO) using a retrospective approach.
methodsA total of 1,086 pregnant women were included, categorized into normal and APO groups. Vitamin B markers during pregnancy, including red blood cell (RBC) and plasma levels of folate (5MTHF), Vitamin B2 (VB2), and Vitamin B6 (VB6), as well as methylmalonic acid (MMA) and homocysteine (HCY), were analyzed. LASSO regression was used for feature selection, followed by logistic regression to develop a predictive model. The model's performance was evaluated using ROC curve, calibration curves, decision curve analysis, and external validation.
resultsHigher plasma-5MTHF, RBC-5MTHF, RBC-VB2, and RBC-VB6 levels were significantly associated with normal pregnancy outcomes, whereas elevated MMA and HCY levels correlated with an increased risk of APO (P < 0.05). In addition, maternal age, pregnancy type, pre-BMI, and passive smoking were identified as significant baseline factors. By integrating these baseline characteristics with Vitamin B-related biomarkers, the predictive model demonstrated excellent performance, with an AUC of 0.85 (95% CI: 0.818-0.883) in the training set and 0.807 (95% CI: 0.738-0.876) in the external validation set.
conclusionAlterations in Vitamin B metabolism are significantly associated with pregnancy outcomes. The developed predictive model provides a valuable tool for risk assessment in clinical practice.
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