Evidence map›Paper›PMID 40604518›Full record

ArticleBMC psychiatry2025

The mediating role of instrumental activities of daily living between cognitive function and depressive symptoms in community-dwelling older adults: the Arao study.

Maiko Nagaoka, Katsuya Nagaoka, Naoto Kajitani, Seiji Yuki, Asuka Koyama, Kazuhiro Yoshiura, Kazuki Honda, Yusuke Miyagawa, Shuken Boku, Noboru Fujise and 1 more

Abstract read
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In one paragraph

Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maiko NagaokaHealth Care Center, Kumamoto University, 2-40-1 Kurokami, Chuo-Ku, Kumamoto, Kumamoto, 860-8555, Japan.
Katsuya NagaokaDepartment of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-Ku, Kumamoto, Kumamoto, 860-8556, Japan.
Naoto KajitaniDepartment of Psychiatry and Neuroscience,Center for Metabolic Regulation of Healthy Aging, Faculty of Life Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-Ku, Kumamoto, Kumamoto, 860-8556, Japan.
Seiji YukiDepartment of Psychiatry, Mashiki Hospital, Mashiki Town, 123 MamizuKamimashiki-Gun, Kumamoto, Kumamoto, 861-2232, Japan.
Asuka KoyamaFaculty of Social Welfare, Kumamoto Gakuen University, 2-5-1 Oe, Chuo-Ku, Kumamoto, Kumamoto, 862-8680, Japan.
Kazuhiro YoshiuraDepartment of Frailty Research, Center for Gerontology and Social Science, Research Institute, National Center for Geriatrics and Gerontology, 7-430 Morioka-Cho, Obu, Aichi, 474-8511, Japan.
Kazuki HondaDepartment of Geriatric Psychiatry, Mitsugumachi Clinic, 135 Mitsugumachi, Kita-Ku, Kumamoto, Kumamoto, 861-5535, Japan.
Yusuke MiyagawaDepartment of Neuropsychiatry, Kumamoto University Hospital, 1-1-1, Honjo, Chuo-Ku, Kumamoto, Kumamoto, 860-8556, Japan.
Shuken BokuDepartment of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757, Ichibancho, Asahimachi-dori, Chuo Ward, Niigata, 951-8510, Japan.
Noboru FujiseMental Wellness Support Center, Kumamoto University, 1-1-1, Honjo, Chuo-Ku, Kumamoto, Kumamoto, 860-8556, Japan.
Minoru TakebayashiDepartment of Psychiatry and Neuroscience,Center for Metabolic Regulation of Healthy Aging, Faculty of Life Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-Ku, Kumamoto, Kumamoto, 860-8556, Japan. mtakebayashi@kumamoto-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe association between cognitive decline and late-life depression (LLD) is well-reported, but few studies have investigated the mediating factors. This study aimed to identify mediating factors between cognitive function and depressive symptoms (outcome), focusing on IADL, in adults aged 65 years and older.

methodsThis cross-sectional study included 1,401 community-dwelling Japanese individuals aged ≥ 65 years. LLD was defined using the Geriatric Depression Scale (GDS). Cognitive function was assessed using the Mini-Mental State Examination Test Form (MMSE), and IADL was evaluated using the Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-IC). Multiple regression and mediation analyses were conducted by fully adjusted potential confounding factors.

resultsAmong the 1,401 participants, the prevalence of late-life depression was 10.2%. In the adjusted multiple regression analysis, IADL demonstrated a significant correlation coefficient and was significantly associated with depressive symptoms (regression coefficient [β] = -0.33, 95% confidence interval [CI] = -0.39 to -0.26). Cognitive function was also significantly associated with depressive symptoms (β = -0.05, CI: -0.09 to -0.01). In the mediation analysis, IADL scores significantly mediated the relationship between cognitive function and depressive symptoms (estimated indirect effect = -0.1000, bootstrap standard error = 0.0142, bootstrap standard CI = -0.1290 to -0.0737).

conclusionsIADL was a mediating factor in the relationship between cognitive function and depressive symptoms, and cognitive function contributed to depressive symptoms through IADL. IADL might play an important role in the prevention and early diagnosis of late-life depression.

Indexed as

Activities of Daily LivingCognitionCognitive DysfunctionDepressionAgedAged, 80 and overCross-Sectional StudiesFemaleGeriatric AssessmentHumansIndependent LivingJapanMalePrevalenceActivity of daily livingCognitive declineDepressionGeriatric psychiatryMediation analysis

Identifiers

PMID40604518
PMCPMC12225066

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.