ArticleBMC geriatrics2025
The association between inflammatory, metabolic, and hepatic fibrosis-related biomarkers and atrial fibrillation in older patients with metabolic dysfunction-associated steatotic liver disease.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Association of red blood cell distribution width to albumin ratio with all-cause and cardiovascular mortality among adults with MASLD.BMC gastroenterology · 2026Article
- Emerging Therapeutic Perspectives in Obese Patients with MASLD Leading to Compensated Advanced Chronic Liver Disease.Biomolecules · 2026Review
- The association between liver fibrosis markers and carotid atherosclerosis in non-alcoholic fatty liver disease is strongly influenced by age.BMC cardiovascular disorders · 2026Article
- Article
- Atrial fibrillation identification in patients with non-alcoholic fatty liver disease: a machine learning model based on immune-inflammatory markers.Diabetology & metabolic syndrome · 2025Article
- Crosstalk Between Metabolic Dysfunction-Associated Steatotic Liver Disease and Atrial Fibrillation: Shared Mechanism, Diagnostic Integration, and Management Implications.Life (Basel, Switzerland) · 2025Review
- Analysis of risk factors associated with metabolic-associated fatty liver disease from Suzhong Region, China: a cross-sectional study.BMJ open · 2025Article
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6 authors.
Funding
Abstract
objectiveThis study aims to explore the associations between biomarkers related to inflammation, metabolism, and liver fibrosis and the prevalence of atrial fibrillation(AF) in older patients with metabolic dysfunction-associated steatotic liver disease (MASLD), and to identify potential indicators that could be conveniently applied in epidemiological studies of AF within this population.
methodsA total of 2035 older patients with MASLD who underwent physical examinations at Northern Jiangsu People's Hospital in Jiangsu Province, China, from January 2021 to June 2023 were selected and divided into AF and non-AF groups. Least Absolute Shrinkage and Selection Operator(LASSO) regression was used for variable selection, and multivariate logistic regression analysis, restricted cubic spline analysis(RCS), subgroup analysis, and predictive model evaluation tools were employed to investigate the associations between these indicators and the risk of AF in older MASLD patients.
resultsBoth LASSO regression and multivariate logistic regression analyses indicated that NAFLD Fibrosis Score(NFS) (OR(95% CI) = 1.924(1.464, 2.558)), Albumin-Bilirubin score(ALBI) (OR (95% CI) = 1.299 (1.156, 1.466)), Fibrosis-4(FIB-4) (OR (95% CI) = 1.385 (1.146, 1.694)), and Monocyte to High-Density Lipoprotein Cholesterol Ratio(MHR)(OR (95% CI) = 1.501 (1.247, 1.809)) are independent risk factors for AF in older patients with MASLD. RCS analysis showed significant non-linear associations between NFS, FIB-4, and MHR and the risk of AF in older MASLD patients (P for nonlinear < 0.05). Subgroup analysis revealed significant interaction effects between diabetes and the AF risk associated with NFS, ALBI, and FIB-4, as well as between sex and the AF risk associated with MHR(P for interaction < 0.05). The variable importance ranking results based on the Boruta algorithm, as well as the Receiver Operating Characteristic (ROC) curve and Decision Curve Analysis (DCA), all indicate that NFS and ALBI have high predictive performance and clinical benefits.
conclusionNFS and ALBI are significantly positively correlated with the prevalence of AF in older patients with MASLD and can serve as potential epidemiological predictive indicators.
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