Evidence map›Paper›PMID 40604471›Full record

ArticleBMC geriatrics2025

Cognitive reserve in subjective cognitive decline with worry: DMN-VN connectivity supports episodic memory under structural vulnerability.

Lanli Jiang, Shaokun Zhao, Ting Li, Jiawen Liu, Junyin Zhang, Zhanjun Zhang, Xin Li

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Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Lanli JiangState Key Laboratory of Cognitive Neuroscience and Learning, Faculty of Psychology, Beijing Normal University, Beijing, 100875, China.
Shaokun ZhaoState Key Laboratory of Cognitive Neuroscience and Learning, Faculty of Psychology, Beijing Normal University, Beijing, 100875, China.
Ting LiState Key Laboratory of Cognitive Neuroscience and Learning, Faculty of Psychology, Beijing Normal University, Beijing, 100875, China.
Jiawen LiuState Key Laboratory of Cognitive Neuroscience and Learning, Faculty of Psychology, Beijing Normal University, Beijing, 100875, China.
Junyin ZhangInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Zhanjun ZhangState Key Laboratory of Cognitive Neuroscience and Learning, Faculty of Psychology, Beijing Normal University, Beijing, 100875, China. zhang_rzs@bnu.edu.cn.
Xin LiState Key Laboratory of Cognitive Neuroscience and Learning, Faculty of Psychology, Beijing Normal University, Beijing, 100875, China. lixin99@bnu.edu.cn.

Funding

State Key Program of National Natural Science of China 82130118STI2030-Major Projects 2022ZD0211600the Natural Science Foundation of China 32171085
6 · The paper itself

Abstract

backgroundThe occurrence of worry in subjects with Subjective Cognitive Decline(SCD) confers a greater risk of future AD and cognitive decline. However, it is not known whether these individuals have distinct memory and neuroimaging profiles. Therefore, we aimed to identify brain imaging characteristics associated with episodic memory in elderly adults with subjective cognitive decline and related worry (SCD+) in a population-based cohort.

methodsA total of 418 individuals from the BABRI cohort underwent structural MRI (n = 418) and episodic memory-related task-based fMRI (n = 153) scans. The subjects were classified into Mild Cognitive Impairment (MCI), SCD+ , SCD, and Normal Control (NC) groups. A brain structure-function-episodic memory pathway model was constructed to investigate potential compensatory mechanisms.

resultsCognitively, SCD+ group did not perform significantly worse than SCD group on episodic memory tasks. For the structural T1-weighted MRI results, gray matter integrity in SCD+ group exhibited altered atrophy patterns compared to SCD, mainly in the posterior hippocampus and parahippocampal cortex. Using PsychoPhysiological Interactions (PPI) to investigate task-based functional connectivity, we found that the SCD+ group exhibited significantly stronger functional connectivity (FC) in the Default Mode Network (DMN) and other networks than SCD. Using moderation model analysis, we found that stronger FC between the DMN and Visual Network (VN) moderated the relationship between gray matter volume (GM) of the posterior hippocampus and episodic memory encoding accuracy within SCD+ group.

conclusionsStronger DMN-VN connectivity may reflect early cognitive reserve processes supporting episodic memory in SCD+ despite structural vulnerability, although such adaptations may vunerable as Alzheimer's disease progresses. Task-based fMRI may serve as a sensitive tool for detecting these processes before clinical decline.

Indexed as

BrainCognitive DysfunctionCognitive ReserveDefault Mode NetworkMemory, EpisodicNerve NetAgedAged, 80 and overCohort StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedCognitive reserveDefault mode networkEpisodic memorySubjective cognitive decline with related worryVisual network

Identifiers

PMID40604471
PMCPMC12220014

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.