Evidence map›Paper›PMID 40604468›Full record

ArticleBMC geriatrics2025

Association between the American heart association's life's essential 8 score and cognitive function: a cross-sectional NHANES study.

Jiuyang Sun, Xinyu Tu, Shuwei Wang, Jie Wang, Jingxue Liang, Zhenguo Liu, Lu Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiuyang Sun *Department of neurology, Xinhua Hospital, Shanghai Jiao tong University School of Medicine, No.1665 Kongjiang Rd, Shanghai, China.
Xinyu Tu *Department of neurology, Xinhua Hospital, Shanghai Jiao tong University School of Medicine, No.1665 Kongjiang Rd, Shanghai, China.
Shuwei WangDepartment of neurology, Xinhua Hospital, Shanghai Jiao tong University School of Medicine, No.1665 Kongjiang Rd, Shanghai, China.
Jie WangDepartment of neurology, Xinhua Hospital, Shanghai Jiao tong University School of Medicine, No.1665 Kongjiang Rd, Shanghai, China.
Jingxue LiangDepartment of neurology, Xinhua Hospital, Shanghai Jiao tong University School of Medicine, No.1665 Kongjiang Rd, Shanghai, China.
Zhenguo LiuDepartment of neurology, Xinhua Hospital, Shanghai Jiao tong University School of Medicine, No.1665 Kongjiang Rd, Shanghai, China. liuzhenguo@xinhuamed.com.cn.
Lu SongDepartment of neurology, Xinhua Hospital, Shanghai Jiao tong University School of Medicine, No.1665 Kongjiang Rd, Shanghai, China. songlu@xinhuamed.com.cn.

Funding

Innovative Research Team of High-level Local University in Shanghai SHSMU-ZDCX20211901Medical Engineering Cross Research Fund of Shanghai Jiao Tong University YG2023ZD12Medical Engineering Cross Research Fund of University of Shanghai for Science and Technology 2023GD-XH06ZNational Natural Science Foundation of China 82171242National Natural Science Foundation of China 82271274
6 · The paper itself

Abstract

backgroundDementia is difficult to early diagnosis while intervention in late stage has limited effectiveness. Our study aimed to explore the associations between a potential risk factor, Life's Essential 8 (LE8), and cognitive performance informs of cognitive test score and subjective cognitive performance.

methodsData were obtained from NHANES 2011-2012 and 2013-2014. Cognitive test score was measured by summary Z-scores of three cognitive test. Subjective cognitive performance was defined by self-reported cognitive problem. Multivariable regression models and restricted cubic spline models were applied to evaluate the association between LE8 score and two cognitive performances. Subgroup analysis and ROC analysis were also conducted to compare the predictive abilities of LE8 on cognitive test score and subjective cognitive performance.

result964 individuals were included in our multivariable regression model (adjusted for age, gender, race, family income, education and alcohol consumption). The LE8 score is positively associated with both cognitive test scores and subjective cognitive performance. The effect of LE8 score on both cognitive test score and subjective cognitive performance showed a trend of linearity. LE8 score and cognitive test score showed a J-shaped dose response relationship. ROC curve indicated that LE8 score predicted better on objective cognitive test score than subjective cognitive performance. Among all LE8 metrics, physical activity, nicotine exposure, blood lipids and blood glucose significantly associated with cognitive test score while only physical activity significantly associated with subjective cognitive performance. Subgroup analysis suggested that LE8 predicted subjective cognitive performance better in high-cognitive test score sub-population than in low-cognitive test score sub-population.

conclusionsLE8 score had significant linear association with both cognitive test score and subjective cognitive performance. LE8 predicted cognitive test score better and the regression coefficient increase more significant as LE8 score increase than subjective cognitive performance. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

American Heart AssociationCognitionDementiaNutrition SurveysAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedNeuropsychological TestsRisk FactorsUnited StatesCognitive dysfunctionNeurodegenerative diseasesRisk factors

Identifiers

PMID40604468
PMCPMC12220781

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.