ArticleBMC microbiology2025
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL- producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epidemiological trends in antibiotic resistant Klebsiella pneumoniae in healthcare settings in Burkina Faso: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- OmpK35/36 modulate the virulence of hypervirulent Klebsiella pneumoniae by regulating capsular polysaccharide export.BMC microbiology · 2026Article
- OmpK35/36 absence does not confer carbapenem-resistance alone nor ceftazidime-avibactam resistance with oneFrontiers in cellular and infection microbiology · 2026Article
- Regional Genomic and Phylogenomic Insights into Multidrug and Colistin-Resistant Klebsiella pneumoniae Strains from Tanzania, Kenya, Uganda, and Ethiopia.Current microbiology · 2025Article
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Authors and funding
8 authors.
Funding
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Abstract
backgroundMultidrug-resistant (MDR) ESBL-producing K. pneumoniae is widely implicated in community and hospital-acquired infections. Thus, the current study determined the prevalence and clonal relatedness of MDR K. pneumoniae from hospital environments, patients and healthcare workers in a Ghanaian hospital.
methodsPatients (rectal and hand, collected on admission and 48 h post admission), healthcare workers (hands) and hospital environment samples were sampled for three months. Antimicrobial susceptibility was determined using VITEK-2. Ten MDR ESBL-producing K. pneumoniae isolates were further analysed by whole-genome sequencing.
resultsAll the isolates were ceftazidime-resistant; 90% were resistant to cefepime, amoxicillin/clavulanic, acid piperacillin/tazobactam, and sulphamethoxazole/trimethoprim. The isolates showed varying resistance to the cephalosporins and were susceptible to tigecycline. One environmental isolate isolate was resistant to meropenem but harboured no carbapenemase gene. The β-lactamase gene, bla
conclusionThis study highlights the prevalence of MDR ESBL-producing K. pneumoniae in both hospital environments and patients, emphasizing the potential for cross-transmission within healthcare settings. These findings reinforce the urgent need for strengthened infection prevention and control measures, enhanced antimicrobial stewardship, and continuous genomic surveillance to mitigate the spread of resistant K. pneumoniae in healthcare settings.
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