ArticleBMC microbiology2025
Disruption of gut microbiome and metabolome in treatment-naïve children with attention deficit hyperactivity disorder.
Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Early Gut Microbiota and Neurodevelopmental Trajectories: Implications for Pediatric Neuropsychiatric Vulnerability-A Narrative Review.Nutrients · 2026Review
- The Gut-Brain Axis as a Mediator of Environmental Endocrine Disruptors in Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Mechanistic Synthesis.Biological psychiatry global open science · 2026Review
- Molecular mechanisms and therapeutic potential of natural products and traditional Chinese medicine formulas in ADHD: a review of preclinical evidence.Frontiers in pharmacology · 2026Review
- Neurodevelopmental disorders and the gut microbiome: insights into ADHD and tic disorders.Frontiers in microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundAttention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with an increasing prevalence in children. Recent studies have suggested that the gut microbiota may play a significant role in the development of ADHD. However, the specific relationship between changes in intestinal bacteria and related metabolites in children with ADHD remains poorly understood.
resultsIn this study, we illustrated the fecal microbiome, metabolome and lipidome, as well as plasma metabolome using 16S rRNA gene sequencing and LC-MS in 15 pairs of children with ADHD and healthy controls. Our results revealed imbalance of gut microbiota and dysregulation of metabolites in individuals with ADHD. Specifically, children with ADHD exhibited significantly lower abundance of the Actinobacteria phylum, particularly Bifidobacterium, Corynebacterium and Actinomyces, while Veillonella in the Negativicutes class showed significant high level. No children with ADHD were classified under enterotype 1, which was composed solely of healthy children. Integration of multi-omics data suggested that the Bifidobacterium genus, which is positively correlated with various neurotransmitter precursor amino acid metabolites, may contribute to ADHD by downregulating pathways involving dopaminergic, serotonergic and glutamatergic systems.
conclusionsThese findings highlight the crucial regulatory impact of gut microbiota in the development of ADHD through metabolic pathways, and provide a potential avenue to the diagnosis and intervention of ADHD.
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Registered trials
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