Evidence map›Paper›PMID 40604365›Full record

ArticleJournal of the Chinese Medical Association : JCMA2025

Macular vessel density is associated with cognitive function in preclinical p.R544C NOTCH3 mutation carriers.

Chien-Chih Chou, Chiao-Ying Liang, Chen-Yu Lin, I-Jong Wang, Chia-Jen Chang, Jun-Peng Chen, Hsin Tung, Hung-Chieh Chen, Hsian-Min Chen, Yi-Ming Chen and 1 more

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Article in Journal of the Chinese Medical Association : JCMA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Chien-Chih ChouGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Chiao-Ying LiangDepartment of Ophthalmology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
Chen-Yu LinDepartment of Ophthalmology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
I-Jong WangGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Chia-Jen ChangDepartment of Ophthalmology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
Jun-Peng ChenBiostatistics Task Force of Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
Hsin TungNeurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
Hung-Chieh ChenSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
Hsian-Min ChenCenter for Quantitative Imaging in Medicine, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
Yi-Ming ChenSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
Wei-Ju LeeDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan, ROC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe study aimed to examine the relationship between retinal microcirculation, brain white matter hyperintensities (WMH) seen on magnetic resonance imaging (MRI), and cognitive decline in asymptomatic carriers of NOTCH3 mutations, a preclinical stage of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.

methodsForty-nine asymptomatic carriers without stroke history or cognitive complaints were studied. Retinal vessel density and WMH volume were measured via optical coherence tomography angiography and MRI, respectively. Cognitive function was assessed using various tests.

resultsIn a multivariable regression model which included both, the whole brain WMH volume and parafoveal vessel density of superficial retinal plexus (SRP) as independent variables, parafoveal vessel density of SRP emerged as a significant predictor for Montreal Cognitive Assessment (MoCA) score ( β = -0.31; 95% confidence interval, -0.1516 to -0.0002; p = 0.044) in this cohort, and consistent findings were observed for Color Trails Tests (CTT)-1 and CTT-2 scores.

conclusionIn asymptomatic NOTCH3 mutation carriers, higher parafoveal vessel density of the SRP may serve as an indicator of cognitive decline, and may also indicate autoregulatory compensatory mechanisms in response to a dysfunctional capillary plexus, potentially signifying early-stage cognitive decline.

Indexed as

CognitionMacula LuteaMutationReceptor, Notch3Retinal VesselsAdultAgedCognitive DysfunctionFemaleHeterozygoteHumansMagnetic Resonance ImagingMaleMiddle AgedNOTCH3 protein, humanReceptor, Notch3Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathyCognitive declineOptical coherence tomography angiographyRetinal microcirculation

Identifiers

PMID40604365
PMCPMC12637145

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.