Evidence map›Paper›PMID 40604325›Full record

ReviewNature biotechnology2025

Unlocking gene regulatory networks for crop resilience and sustainable agriculture.

Richalynn Leong, Xin He, Bob Sebastiaan Beijen, Toshiyuki Sakai, Jorge Goncalves, Pingtao Ding

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Artificial Intelligence for Plant Gene Regulatory Networks.International journal of molecular sciences · 2026
    Review
  2. Review
  3. Review
  4. Artificial intelligence-driven advancements in agricultural biotechnology.Journal, genetic engineering & biotechnology · 2026
    Review
  5. Single-cell insights into plant growth, adaptation, and evolution.Journal of integrative plant biology · 2026
    Review
  6. Adaptive Responses of Tropical Crops: A Multi-Scale Omics Integrated Perspective.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Richalynn Leong *Institute of Biology Leiden, Leiden University, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-5265-5354
Xin He *Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.ORCID http://orcid.org/0000-0003-2758-4360
Bob Sebastiaan Beijen *Institute of Biology Leiden, Leiden University, Leiden, the Netherlands.
Toshiyuki SakaiCrop Evolution Laboratory, Kyoto University, Muko, Japan.ORCID http://orcid.org/0000-0003-2737-3299
Jorge GoncalvesLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.ORCID http://orcid.org/0000-0002-5228-6165
Pingtao DingInstitute of Biology Leiden, Leiden University, Leiden, the Netherlands. p.ding@biology.leidenuniv.nl.ORCID http://orcid.org/0000-0002-3535-6053

Funding

Fonds National de la Recherche Luxembourg (National Research Fund) 11012546
6 · The paper itself

Abstract

Understanding the complex mechanisms of gene regulatory networks (GRNs) has emerged as a transformative approach in agricultural research. By deciphering the regulatory mechanisms underlying key traits, GRN studies offer opportunities to enhance crop resilience to environmental challenges, improve yield and ensure sustainable food production. In this Review, we highlight the importance of GRN research in agriculture and explore how cutting-edge biotechnology, interdisciplinary approaches and computational modeling techniques are addressing the challenges in the field. We discuss how integrating diverse datasets at different resolutions empowers us to unravel the complex genetic networks governing crop responses to climate change, pests and diseases. By harnessing the power of GRNs, we have the potential to transform crop improvement strategies, develop stress-tolerant varieties and ensure global food security. We provide insights into the current opportunities and challenges of GRN research in agriculture, bridging the gap between scientific advancements and the pressing need for sustainable agricultural practices.

Indexed as

AgricultureCrops, AgriculturalGene Regulatory NetworksBiotechnologyClimate ChangeGene Expression Regulation, Plant

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.