Evidence map›Paper›PMID 40604300›Full record

ArticleNpj imaging2025

3D imaging of the human temporal bone by X-ray phase-contrast tomography.

Jannis J Schaeper, Paul Tafforeau, Christoph A Kampshoff, Carolina Thomas, Alexander Meyer, Christine Stadelmann, M Charles Liberman, Tobias Moser, Tim Salditt

Abstract read
In one paragraph

Article in Npj imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jannis J SchaeperInstitute for X-ray Physics, University of Göttingen, Göttingen, Germany.
Paul TafforeauBeamline BM18, European Synchrotron Radiation Facility, Grenoble, France.
Christoph A KampshoffInstitute for Auditory Neuroscience, University Medical Center Göttingen, Göttingen, Germany.
Carolina ThomasCluster of Excellence "Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells", University of Göttingen, Göttingen, Germany.
Alexander MeyerDepartment of Otolaryngology, University Medical Center Göttingen, Göttingen, Germany.
Christine StadelmannCluster of Excellence "Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells", University of Göttingen, Göttingen, Germany.
M Charles LibermanEaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.
Tobias MoserCluster of Excellence "Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells", University of Göttingen, Göttingen, Germany.
Tim SaldittInstitute for X-ray Physics, University of Göttingen, Göttingen, Germany. tsaldit@gwdg.de.

Funding

Bundesministerium für Bildung und Forschung EXC 2067/1- 390729940
6 · The paper itself

Abstract

Studying the subtle and intricate three-dimensional structure of the human cochlea embedded in the temporal bone requires structure-preserving imaging approaches with adaptable field of view and resolution. Synchrotron X-ray phase-contrast tomography at the novel beamline BM18 (EBS, ESRF) offers the unique capability to achieve histological resolution at the scale of the entire organ, based on high lateral coherence, long propagation distances, and optimized spectral range. At the same time advances in laboratory μ-CT instrumentation and protocols also open up new opportunities for 3D micro-anatomy and histopathology, including 3D reconstruction of nerve tissue when suitable staining protocols are used. Here we report on post mortem 3D imaging of human temporal bones and excised human cochleae, both unstained and stained to visualize the auditory nerve. Further, we highlight the use of this imaging modality for development of novel cochlear implant technology.

Identifiers

PMID40604300
PMCPMC12118726

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.