Evidence map›Paper›PMID 40604283›Full record

ArticleNature2025

Functional amyloid proteins confer defence against predatory bacteria.

Hannah E Ledvina, Ryan Sayegh, Ricardo O Carale, A Maxwell Burroughs, Alexa R Macklin, Ashley L Azadeh, Layla D Borja Najera, L Aravind, Aaron T Whiteley

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Oral Actinobacteria sense and defend against parasitic epibionts.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. bioRxiv : the preprint server for biology · 2026
    Article
  6. A functional amyloid scaffold shapes insect egg coats.bioRxiv : the preprint server for biology · 2026
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  12. Enrichment isolation and metabolic characteristics ofApplied and environmental microbiology · 2025
    Article
  13. Amyloid-mediated RNA uptake by sperm for embryonic delivery.bioRxiv : the preprint server for biology · 2025
    Article
  14. Review
  15. Article
  16. Curli-independent defense againstMicrobiology spectrum · 2025
    Article
  17. Body armour keeps predators away.Nature reviews. Microbiology · 2025
    Article
  18. Amyloids in bacterial antiphage defence.Nature microbiology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Hannah E LedvinaDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.
Ryan SayeghDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.
Ricardo O CaraleDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.
A Maxwell BurroughsComputational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-2229-8771
Alexa R MacklinDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.
Ashley L AzadehDepartment of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA.
Layla D Borja NajeraDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.
L AravindComputational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0771-253X
Aaron T WhiteleyDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA. aaron.whiteley@colorado.edu.ORCID 0000-0002-0075-7519

Funding

Evolutionary Analysis and Comparative Genomics of Protein SuperfamiliesZIALM594244 · NLM · NATIONAL LIBRARY OF MEDICINE · PI ARAVIND, L · 2009 to 2025
$20.3M
Predoctoral Training Program in Signaling and Cellular Regulation INCLUDE Down Syndrome SupplementT32GM142607 · NIGMS · UNIVERSITY OF COLORADO · PI Sabrina Leigh Spencer, Tin Tin Su · 2021 to 2026
$3.6M
Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed)DP2AT012346 · NCCIH · UNIVERSITY OF COLORADO · PI WHITELEY, AARON THOMAS · 2022 to 2025
$2.4M
Laser Scanning Confocal MicroscopeS10OD034320 · OD · UNIVERSITY OF COLORADO · PI DRAGAVON, JOSEPH · 2023 to 2023
$445k
Intramural NIH HHS ZIA LM594244NCCIH NIH HHS DP2 AT012346NIGMS NIH HHS T32 GM142607NIH HHS S10 OD034320
6 · The paper itself

Abstract

Bdellovibrio bacteriovorus is a predatory bacterium that non-selectively preys on Gram-negative bacteria by invading the prey-cell periplasm, leaching host nutrients and ultimately lysing the infected cell to exit and find a new host

Indexed as

AmyloidAmyloidogenic ProteinsBacterial ProteinsBdellovibrio bacteriovorusEscherichia coliBacteriophagesBiofilmsEscherichia coli ProteinsMyxococcus xanthusAmyloidAmyloidogenic ProteinsBacterial ProteinscsgA protein, E coliEscherichia coli Proteins

Identifiers

PMID40604283
PMCPMC12419547

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.