ArticleNature2025
The mutagenic forces shaping the genomes of lung cancer in never smokers.
Registry-linked trialAbstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07383454 (Lung Cancer Screening in Population Who Had Never Smoked and the Validation of Lung Cancer Risk Prediction Model), which is not on this map. Cited by 42 papers.
0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lung Cancer Screening in Population Who Had Never Smoked and the Validation of Lung Cancer Risk Prediction Model
Who cites it
42 citing papers in PubMed.
- The shifting burden of tracheal, bronchus and lung cancer in ageing Asia: structural drivers and projections to 2050.Annals of medicine · 2026Article
- Genomic instability, postoperative recurrence and therapeutic vulnerabilities in resectable non‑small cell lung cancer (Review).Oncology reports · 2026Review
- Review
- Improving neoadjuvant and perioperative therapy in non-small-cell lung cancer.Nature reviews. Clinical oncology · 2026Review
- Motif-centered analyses reveal universal and tissue-specific mutagenic mechanisms operating in the human body.NAR cancer · 2026Article
- Breathing carcinogens: PMJournal of thoracic disease · 2026Review
- Sex-specific associations of the bilirubin-to-albumin ratio with lung cancer risk: evidence from Cox regression and causal survival forest analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Hallmarks of lung cancer driven by inhalable particulate matter: From cell-intrinsic oncogenic traits to microenvironment remodeling.Innovation (Cambridge (Mass.)) · 2026Review
- Worldwide Innovative Network Consortium: Building a Common Global Cancer Database.JCO global oncology · 2026Review
- Phenolic Endocrine-Disrupting Chemical Exposure and Systemic Biomarker Variability in Patients with Lung Cancer.Medicina (Kaunas, Lithuania) · 2026Article
- Germline determinants of risk and molecular subtype in young-onset lung cancer.medRxiv : the preprint server for health sciences · 2026Article
- Immune Regulation and the Role of Extracellular Vesicles in Non-Small Cell Lung Cancer: Biological Mechanisms and Therapeutic Perspectives.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Real-World Evaluation of Next-Generation Sequencing in Lung Cancer: Associations Between Histological Subtypes and Genomic Alterations.Current issues in molecular biology · 2026Article
- A Roadmap to Transform Lung Cancer Outcomes: Priorities in Biology, Therapeutic Innovation, Early Detection, Prevention, and Interception.Cancer discovery · 2026Review
- Stage shifts in national lung adenocarcinoma and the impact of opportunistic self-initiated LDCT screening in Taiwan: a nationwide population-based cohort study.The Lancet regional health. Western Pacific · 2026Article
- Motif-Centered Analyses Reveal Universal and Tissue-Specific Mutagenic Mechanisms Operating in the Human Body.bioRxiv : the preprint server for biology · 2026Article
- Screening air pollutants-related genes to construct a prognostic risk model for lung adenocarcinoma and analyzing its immune microenvironment.Journal of thoracic disease · 2026Article
- Review
- Global Cancer Etiology: Molecular Signatures, Therapeutic Disparities, and the role of Socio-economic Determinants.Chemical biology letters · 2026Article
- Global impact of germline structural variation on the cancer proteome.Nature communications · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
69 authors.
Marcos Díaz-Gay *Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-0658-0467
Tongwu Zhang *Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0003-2124-2706
Phuc H HoangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-9265-8525
Charles LeducDepartment of Pathology, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
Marina K BaineDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
William D TravisDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lynette M ShollDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-9532-9735
Philippe JoubertInstitut Universitaire de Cardiologie et de Pneumologie de Québec - Université Laval, Quebec City, Quebec, Canada.
Azhar KhandekarDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Wei ZhaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0001-5103-3871
Christopher D SteeleDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Burçak OtluDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Shuvro P NandiDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-4855-4697
Raviteja VangaraDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-5272-6207
Erik N BergstromDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Mariya KazachkovaDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Oriol PichCancer Evolution and Genome Instability Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0002-1956-1882
Charles SwantonCancer Evolution and Genome Instability Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0002-4299-3018
Chao Agnes HsiungInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
I-Shou ChangNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.
Maria Pik WongQueen Mary Hospital, University of Hong Kong, Hong Kong, China.
Kin Chung LeungDepartment of Pathology, University of Hong Kong, Hong Kong, China.
Jian SangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
John P McElderryDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Caleb HartmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID 0009-0009-9378-3967
Frank J Colón-MatosDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Mona MiraftabDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Monjoy SahaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Olivia W LeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0001-5389-6267
Kristine M JonesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0003-1584-8920
Pilar Gallego-GarcíaDigital Genomics Group, Cancer Genomics Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.ORCID 0000-0001-8531-9851
Yang YangBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-5560-2936
Xiaoming ZhongBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA.
Eric S EdellDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.
Jacobo Martínez SantamaríaBiobanco IBSP-CV FISABIO, Valencia, Spain.ORCID 0009-0000-4351-3955
Matthew B SchabathDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.ORCID 0000-0003-3241-3216
Sai S YendamuriThoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Marta ManczukDepartment of Cancer Epidemiology and Primary Prevention, Maria Skłodowska-Curie National Research Institute of Oncology, Warsaw, Poland.ORCID 0000-0002-4319-6424
Jolanta LissowskaDepartment of Cancer Epidemiology and Primary Prevention, Maria Skłodowska-Curie National Research Institute of Oncology, Warsaw, Poland.ORCID 0000-0003-2695-5799
Beata ŚwiątkowskaDepartment of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland.ORCID 0000-0003-3757-3868
Anush MukeriaDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
Oxana ShanginaDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
David ZaridzeDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
Ivana HolcatovaInstitute of Public Health and Preventive Medicine, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
Dana MatesDepartment of Occupational Health and Toxicology, National Center for Environmental Risk Monitoring, National Institute of Public Health, Bucharest, Romania.
Sasa MilosavljevicInternational Organization for Cancer Prevention and Research (IOCPR), Belgrade, Serbia.
Milica KonticClinic of Pulmonology, Clinical Center of Serbia, Belgrade, Serbia.
Yohan BosséInstitut Universitaire de Cardiologie et de Pneumologie de Québec - Université Laval, Quebec City, Quebec, Canada.ORCID 0000-0002-3067-3711
Bonnie E Gould RothbergSylvester Comprehensive Cancer Center, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0000-0002-8919-4467
David C ChristianiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-0301-0242
Valerie GaborieauGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Paul BrennanGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Geoffrey LiuPrincess Margaret Cancer Center, University of Toronto, Toronto, Ontario, Canada.
Paul HofmanIHU RespirERA, Biobank-BB-0033-0025, Côte d'Azur University, Nice, France.ORCID 0000-0003-0431-9353
Lixing YangBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA.
Martin A NowakDepartment of Mathematics, Harvard University, Cambridge, MA, USA.
Jianxin ShiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0001-8606-4707
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
David C WedgeManchester Cancer Research Centre, University of Manchester, Manchester, UK.ORCID 0000-0002-7572-3196
Robert HomerDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-2055-5885
Soo-Ryum YangDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Angela C PesatoriDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.ORCID 0000-0002-0261-3252
Dario ConsonniFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0002-8935-3843
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-0888-8839
Bin ZhuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0003-0172-5516
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-2324-3393
Jiyeon ChoiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-0955-2384
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. L2alexandrov@health.ucsd.edu.ORCID 0000-0003-3596-4515
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. landim@nih.gov.ORCID 0000-0003-4507-329X
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MTRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5MStudies of Genetic and Environmental EpidemiologyZIACP101231 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI LANDI, MARIA · 2018 to 2025
$23.6MStatistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9MDetecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer PreventionR01ES032547 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALEXANDROV, LUDMIL B · 2021 to 2025
$3.4MMapping immuno-genomic drivers of the head and neck precancer invasive-disease transitionU01CA290479 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Jorge Silvio Gutkind · 2023 to 2026
$3.1MComprehensive identification of germline-somatic interactionsR01CA269919 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Hannah Kathryn Carter · 2022 to 2026
$2.2MIntramural NIH HHS ZIA CP101231NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA269919NCI NIH HHS R35 CA197449NCI NIH HHS U01 CA290479NIEHS NIH HHS R01 ES032547World Health Organization 001
Abstract
Lung cancer in never smokers (LCINS) accounts for around 25% of all lung cancers
Indexed as
Genome, HumanLung NeoplasmsMutagenesisMutationNon-SmokersAdenocarcinomaAgedAir PollutionErbB ReceptorsEuropeFemaleHumansMaleMiddle AgedProto-Oncogene Proteins p21(ras)Tobacco Smoke PollutionEGFR protein, humanErbB ReceptorsKRAS protein, humanProto-Oncogene Proteins p21(ras)Tobacco Smoke PollutionTP53 protein, humanTumor Suppressor Protein p53
Identifiers
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Read underepoch 390
Registered trials
NCT07383454ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.