ArticleNature2025
Range extender mediates long-distance enhancer activity.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Epigenetic regulation of vertebrate limb development: from field specification to tissue morphogenesis.Epigenetics · 2026Review
- Robust regulatory interplay of enhancers, facilitators, and promoters in a native chromatin context.Cell · 2026Article
- Non-coding regulatory variants in adolescent idiopathic scoliosis risk and pathogenesis.Communications biology · 2026Review
- Mechanisms and functional implications of long-range enhancer-dependent gene regulation.Nature genetics · 2026Review
- Predictive design of tissue-specific mammalian enhancers that function in the mouse embryo.Nature genetics · 2026Article
- Transcription factors as drivers of 3D enhancer-promoter interactions.Current opinion in structural biology · 2026Review
- Cohesin-mediated loop extrusion and enhancer-associated factors additively contribute toGenes & development · 2026Article
- Metadomain and metaloop genome interactions in mammalian T cells.Cell reports · 2026Article
- Genome-Wide Annotation of Promoter-Enhancer Interactions via Chromatin Loops in the Hybrid Rat Diversity Panel.bioRxiv : the preprint server for biology · 2026Article
- Review
- Genomic approaches for understanding the evolution of the human brain.Nature neuroscience · 2026Review
- Facilitators may represent a new class of regulatory elements.Current opinion in genetics & development · 2026Review
- Loop Extrusion Accelerates Long-Range Enhancer-Promoter Searches in Living Embryos.bioRxiv : the preprint server for biology · 2026Article
- Synergy between regulatory elements can render cohesin dispensable for distal enhancer function.Science (New York, N.Y.) · 2026Article
- MER57E3 transposable elements regulate gene expression in a human cell model of neural development.Genome biology · 2026Article
- Review
- Temporal constraints on enhancer usage shape the regulation of limb gene transcription.Nature communications · 2026Article
- Visualizing genetic information flow in space and time.Science China. Life sciences · 2025Review
- The inbred newt genome unveils molecular mechanisms of behavior, development, and regeneration in urodele amphibians.iScience · 2025Article
- Learning induces persistent chromatin loops underlying robust gene expression during memory recall.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
- Update ofConserved2024
Authors and funding
17 authors.
Grace BowerDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.ORCID 0000-0003-1104-604X
Ethan W HollingsworthDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Sandra H JacintoDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Joshua A AlcantaraDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Benjamin ClockDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Kaitlyn CaoDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Mandy LiuDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Adam DziulkoEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Ana Alcaina-CaroCentro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide-Junta de Andalucía, Seville, Spain.ORCID 0000-0002-7352-5890
Qianlan XuDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA.
Dorota Skowronska-KrawczykDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA.ORCID 0000-0002-5758-4225
Javier Lopez-RiosCentro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide-Junta de Andalucía, Seville, Spain.ORCID 0000-0001-6731-3798
Diane E DickelEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Anaïs F BardetInstitut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, CNRS UMR7104, INSERM U1258, Illkirch, France.ORCID 0000-0003-2306-7809
Len A PennacchioEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID 0000-0002-8748-3732
Axel ViselEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID 0000-0002-4130-7784
Evgeny Z KvonDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA. ekvon@uci.edu.ORCID 0000-0002-1562-0945
Funding
Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9MGeneration of an In Vivo Human Genome Transcriptional Enhancer DatasetR01HG003988 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Len Alexander Pennacchio · 2006 to 2026
$24.1MMEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1MTraining Program in Stem Cell Translational Medicine for Neurological DisordersT32NS082174 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PETER John DONOVAN, Leslie Michels Thompson · 2013 to 2026
$3.3MDeciphering the mechanism of long-range gene regulation in vivoDP2GM149555 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI KVON, EVGENY · 2022 to 2025
$2.4MDecoding the Mechanism of Pathogenic Enhancer Mutations In Congenital Limb DisordersR01HD115268 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI Evgeny Kvon · 2024 to 2026
$1.2MHigh-Throughput DNA SequencerS10OD021718 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2016 to 2016
$600kPacBio RS Single Molecule, Real-Time (SMRT) DNA SequencerS10OD010794 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2012 to 2012
$600kHigh Throughput DNA SequencerS10RR025496 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2009 to 2009
$500kDeciphering Mechanisms of Limb Malformations Caused by Noncoding Variants In VivoF30HD110233 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI Ethan W Hollingsworth · 2022 to 2026
$189kCharacterizing a mechanism of enhancer-promoter interaction in vivoF31HD112201 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI BOWER, GRACE CABOT · 2023 to 2025
$136kNCI NIH HHS P30 CA062203NCRR NIH HHS S10 RR025496NHGRI NIH HHS R01 HG003988NICHD NIH HHS F30 HD110233NICHD NIH HHS F31 HD112201NICHD NIH HHS R01 HD115268NIGMS NIH HHS DP2 GM149555NIGMS NIH HHS T32 GM008620NIH HHS S10 OD010794NIH HHS S10 OD021718NINDS NIH HHS T32 NS082174
Abstract
Although most mammalian transcriptional enhancers regulate their cognate promoters over distances of tens of kilobases, some enhancers act over distances in the megabase range
Indexed as
Enhancer Elements, GeneticAnimalsConserved SequenceExtremitiesFemaleHedgehog ProteinsMiceNucleotide MotifsPromoter Regions, GeneticTranscription FactorsHedgehog ProteinsShh protein, mouseTranscription Factors
Identifiers
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.