Evidence map›Paper›PMID 40604266›Full record

ReviewNature protocols2026

Three-dimensional robotic structures fabricated and powered entirely with proteins.

Haiyang Jia, Huan Sun, Johannes Flommersfeld, Wentao Shi, Frank Siedler, Petra Schwille

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haiyang Jia *School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, People's Republic of China. haiyangjia@bit.edu.cn.ORCID 0000-0002-8330-5031
Huan Sun *The Institute of Medicinal Plant Development (IMPLAD), Beijing, People's Republic of China.
Johannes FlommersfeldDepartment of Physics and Astronomy, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Wentao ShiSchool of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, People's Republic of China.
Frank SiedlerMax Planck Institute of Biochemistry, Martinsried, Germany.ORCID 0009-0003-4447-6043
Petra SchwilleMax Planck Institute of Biochemistry, Martinsried, Germany. schwille@biochem.mpg.de.ORCID 0000-0002-6106-4847

Funding

Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) MaxSynBioMax-Planck-Gesellschaft (Max Planck Society) MaxSynBioNational Natural Science Foundation of China (National Science Foundation of China) 2247081930National Natural Science Foundation of China (National Science Foundation of China) 3240120176
6 · The paper itself

Abstract

Assembling and upscaling biomolecular activity to perform work in man-made devices is a challenge in synthetic biology. Here we report the step-by-step process to construct fully protein-based micro-three-dimensional (3D) printed robotic structures, which are coated with and actuated by a minimal actomyosin cortex. This approach can be used to program self-powered soft robots assembled from multiple biomolecular modules, devising biophysical assays to quantify active forces produced in 3D and engineering smart 3D microchips for synthetic cell assembly. The procedure covers the establishment of 3D printing microstructures from protein materials, the assembly of actomyosin-based active coatings and the robotic structure design and characterization. The detailed step-by-step instructions will guide scientists in replicating the preparation procedures, facilitating the adoption of biomolecular microrobots and the development of 3D protein-based robotic technology and their applications. The procedure is suited for users with expertise in biomaterials and requires 15 d to complete.

Indexed as

Printing, Three-DimensionalProteinsRoboticsActomyosinSynthetic BiologyActomyosinProteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.