ArticleCommunications medicine2025
Quality of life and mental health in children with long COVID.
Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- Management of long COVID-19 in children and adolescents: from diagnosis to therapeutically approaches.Annals of medicine · 2026Review
- A call to educate: counteracting enacted stigma in children with long COVID.Pediatric research · 2026Article
- Which healthcare services did children and adolescents use before presentation at specialised outpatient clinics for post-COVID-19 condition? Descriptive findings from the Post-COVID Kids Bavaria study.BMJ paediatrics open · 2026Article
- Beyond functional independence: symptom burden and emotional difficulties in pediatric long COVID-a cross-sectional exploratory study.Frontiers in pediatrics · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPediatric Long COVID (PLC) is a heterogeneous condition, which can have a substantial impact on daily life of children and adolescents. This study aimed to evaluate health related quality of life (HRQoL), and mental and social health of children with PLC, in relation to children with other chronic health conditions (CHC) and from the general population (GP) during the pandemic.
methodsDutch children (8-18 years) with PLC (n = 106, 31% male) were included between May 2021 and March 2023. Reference data was available from a CHC-cohort (n = 90, 56% male) and GP-cohort (n = 844, 47% male) during the first wave of the pandemic (April-May, 2020). Participants completed the Pediatric Quality of Life Inventory (PedsQL) 4.0 and Patient-Reported Outcomes Measurement Information System (PROMIS) instruments (Anxiety, Anger, Depressive symptoms, Sleep-Related Impairment (SRI), and Peer Relationships). Mean scores were analyzed using adjusted ANCOVA. Relative risks (RR (95% CI)) were calculated for impaired HRQoL and severe PROMIS scores.
resultsChildren with PLC report high proportions of impaired HRQoL (84%, RR = 3.67 (2.35-5.74)), and have significantly lower PedsQL scores than children with CHC. Children with PLC also exhibit worse PROMIS T-scores of Anxiety, Depressive Symptoms, and SRI than children from the CHC- and GP-cohorts (mean difference range 2.2-9.8 (95%CI 0.6-11.7)), and significantly higher risks of severe anxiety (17%), depressive symptoms (18%), and SRI (17%).
conclusionsPLC can severely impact HRQoL and mental and social health in children. Screening of these outcomes and individualized management of children with PLC should be a vital part of clinical care for these highly burdened patients.
Identifiers
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Registered trials
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