Evidence map›Paper›PMID 40604226›Full record

ArticleScientific reports2025

Preoperative renal functional reserve as a predictor of acute kidney injury in young adults with congenital heart disease.

Dana Y Fuhrman, George J Schwartz, David S Cooper, Victor B Talisa, Arvind K Hoskoppal, John A Kellum

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dana Y FuhrmanDepartment of Pediatrics, Division of Nephrology, UPMC Children's Hospital of Pittsburgh, 4401 Penn Avenue, Suite 2000, Pittsburgh, PA, 15224, USA. dana.fuhrman@chp.edu.ORCID https://orcid.org/0000-0002-3672-7960
George J SchwartzDepartment of Pediatrics, Division of Pediatric Nephrology, University of Rochester Medical Center, Rochester, NY, USA.
David S CooperDepartment of Pediatrics, The Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Victor B TalisaDepartment of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Arvind K HoskoppalDepartment of Pediatrics, Division of Pediatric Cardiology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
John A KellumProgram for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

Renal Fitness in Young Adults with Congenital Heart DiseaseK23DK116973 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FUHRMAN, DANA YOUNG · 2019 to 2023
$1.2M
NIDDK NIH HHS K23 DK116973NIDDK NIH HHS K23DK116973NIDDK NIH HHS L30 DK122411
6 · The paper itself

Abstract

Due to advances in medical and surgical care, there are more adults than children living with congenital heart disease (CHD). Acute kidney injury (AKI) is a common complication following cardiac surgery in patients with CHD, with creatinine lacking sensitivity for early detection. Renal functional reserve (RFR), the kidney's capacity to increase filtration under stress, has emerged as a potential predictor of AKI. Our primary study objective was to evaluate whether preoperative RFR, using both creatinine clearance (CrCl) and cystatin C estimated glomerular filtration rate (eGFR) methods, predicts AKI following cardiopulmonary bypass in young adults with CHD. As a secondary objective, we compared RFR in CHD patients to that of healthy controls. This prospective cohort study included 30 young adults (ages 18-40) with acyanotic CHD and 8 healthy controls with normal baseline kidney function by serum creatinine. Preoperative RFR was measured using CrCl and cystatin C eGFR before and after a protein load. Postoperative AKI was diagnosed using the Kidney Disease Improving Global Outcomes criteria. Twelve (40%) CHD patients developed AKI, exhibiting significantly lower RFR when compared to those without AKI (median CrCl RFR: 9.6 vs. 35.0 mL/min/1.73m

Indexed as

Acute Kidney InjuryHeart Defects, CongenitalKidneyAdolescentAdultBiomarkersCardiopulmonary BypassCreatinineCystatin CFemaleGlomerular Filtration RateHumansKidney Function TestsMalePostoperative ComplicationsPreoperative PeriodBiomarkersCreatinineCystatin CAcute kidney injuryCongenital heart diseaseRenal functional reserveStress GFR

Identifiers

PMID40604226
PMCPMC12223075

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.