Evidence map›Paper›PMID 40604198›Full record

ArticleScientific reports2025

Quantum chemical modeling, molecular docking, and ADMET evaluation of imidazole phenothiazine hybrids.

Deepanjali Shukla, Iqbal Azad, Sabahat Yasmeen Sheikh, Saud Nusrat Ali, Naseem Ahmad, Azhar Kamal, Mohd Faiyyaz, Abdul Rahman Khan, Varish Ahmad, Anwar A Alghamdi and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Deepanjali ShuklaDepartment of Chemistry, Integral University, Dasauli, P.O. Bas-ha, Kursi Road, Lucknow, UP, 226026, India.
Iqbal AzadDepartment of Chemistry, Integral University, Dasauli, P.O. Bas-ha, Kursi Road, Lucknow, UP, 226026, India.
Sabahat Yasmeen SheikhDepartment of Chemistry, Integral University, Dasauli, P.O. Bas-ha, Kursi Road, Lucknow, UP, 226026, India.
Saud Nusrat AliDepartment of Chemistry, Integral University, Dasauli, P.O. Bas-ha, Kursi Road, Lucknow, UP, 226026, India.
Naseem AhmadDepartment of Chemistry, Integral University, Dasauli, P.O. Bas-ha, Kursi Road, Lucknow, UP, 226026, India.
Azhar KamalDepartment of Bioengineering, Integral University, Dasauli, P.O. Bas-ha, Kursi Road, Lucknow, 226026, UP, India.
Mohd FaiyyazDepartment of Chemistry, Integral University, Dasauli, P.O. Bas-ha, Kursi Road, Lucknow, UP, 226026, India.
Abdul Rahman KhanDepartment of Chemistry, Integral University, Dasauli, P.O. Bas-ha, Kursi Road, Lucknow, UP, 226026, India.
Varish AhmadHealth Information Technology Department, The Applied College, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Anwar A AlghamdiHealth Information Technology Department, The Applied College, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Malik NasibullahDepartment of Chemistry, Integral University, Dasauli, P.O. Bas-ha, Kursi Road, Lucknow, UP, 226026, India.
Firoj HassanDepartment of Chemistry, Integral University, Dasauli, P.O. Bas-ha, Kursi Road, Lucknow, UP, 226026, India. firoz@iul.ac.in.

Funding

Deanship of Scientific Research (D.S.R.), King Abdulaziz University, Jeddah, Saudi Arabia, under Grant no. (KEP-2http://-140-41). Grant no. (KEP-2-140-41)
6 · The paper itself

Abstract

Cancer is one of the biggest challenges for health concerns in the world. There are so many drugs available, but they have a lack of specificity, poor safety, side effects, and the development of resistance. Therefore, there is an urgent need for much safer and more targeted anticancer treatments. Nitrogen-containing heterocycles play an important role in the development of drugs. Recently, imidazole and phenothiazine rings are well known for their antiproliferative and anticancer activities. This study employs the molecular hybridisation method to link these bioactive scaffolds and develop novel N-substituted imidazole-phenothiazine (N-IPTZ) hybrids. All the synthesised hybrids were characterised by using analytical techniques such as

Indexed as

Antineoplastic AgentsImidazolesMolecular Docking SimulationPhenothiazinesCell ProliferationErbB ReceptorsHumansQuantum TheoryVascular Endothelial Growth Factor Receptor-2Antineoplastic AgentsErbB ReceptorsimidazoleImidazolesphenothiazinePhenothiazinesVascular Endothelial Growth Factor Receptor-2DFTEGFR inhibitorHepG2 cell lineImidazoleMD simulationMolecular dockingPhenothiazine

Identifiers

PMID40604198
PMCPMC12223006

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.