ArticleScientific reports2025
Sex-specific associations of fat and lean indices with vertebral fractures.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Muscle mass, not fat mass, predicts vertebral fracture risk: Vietnam osteoporosis study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Muscle mass, not fat mass, predicts vertebral fracture risk: Vietnam osteoporosis study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
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2 authors.
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Abstract
The relationship between body composition and fracture sites is complex. Previous studies have reported that a site-dependent relationship between body mass index (BMI) and fractures in postmenopausal women and older men. This study aimed to investigate sex-specific associations of fat and lean indices with vertebral fractures. This cross-sectional study included 1,479 participants, with body composition assessed using dual-energy X-ray absorptiometry. Fat indices included BMI, body fat percentage, and waist circumference, whereas the lean index was represented by appendicular lean mass (ALM)/height². Prevalent vertebral fractures were identified through radiographic confirmation. When both fat and lean indices simultaneously were considered, BMI (odds ratio [OR], 1.15; 95% confidence interval [CI] 1.08-1.22), body fat percentage (OR, 1.06; 95% CI 1.02-1.10), and waist circumference (OR, 1.06; 95% CI, 1.03-1.08) were significantly associated with vertebral fractures in postmenopausal women, whereas ALM/height² did not show such an association. In contrast, for men aged ≥ 50 years, ALM/height² was significantly associated with vertebral fractures, whereas fat indices showed no such an association. Furthermore, a significant interaction between ALM/height² and sex was observed. Fat indices were predominantly associated with vertebral fractures in women, whereas the lean index was more strongly associated with vertebral fractures in men. These findings highlight a sex-specific association between body composition and vertebral fractures.
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