Evidence map›Paper›PMID 40604170›Full record

ArticleNpj imaging2025

Aldehydic load as an objective imaging biomarker of mild traumatic brain injury.

Alexia Kirby, Cian Ward, Clara S Goulet, Nicholas D Calvert, Ryan Daniel, Joseph Wai-Hin Leung, Ashwin Sharma, Mojmír Suchý, Cassandra Donatelli, Jing Wang and 2 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Npj imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Alexia KirbyDepartment of Biology, University of Ottawa, Ottawa, ON, Canada.
Cian WardDepartment of Biology, University of Ottawa, Ottawa, ON, Canada.
Clara S GouletDepartment of Biology, University of Ottawa, Ottawa, ON, Canada.
Nicholas D CalvertUniversity of Ottawa Heart Institute, Ottawa, ON, Canada.
Ryan DanielDepartment of Biology, University of Ottawa, Ottawa, ON, Canada.
Joseph Wai-Hin LeungDepartment of Biology, University of Ottawa, Ottawa, ON, Canada.
Ashwin SharmaDepartment of Biology, University of Ottawa, Ottawa, ON, Canada.
Mojmír SuchýUniversity of Ottawa Heart Institute, Ottawa, ON, Canada.
Cassandra DonatelliDepartment of Biology, University of Ottawa, Ottawa, ON, Canada.
Jing WangRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Emily StandenDepartment of Biology, University of Ottawa, Ottawa, ON, Canada.
Adam J ShuhendlerDepartment of Biology, University of Ottawa, Ottawa, ON, Canada. adam.shuhendler@uottawa.ca.

Funding

Canada Research Chairs 950-230754CIHR PJT-376892Government of Ontario ER18-14-102Natural Sciences and Engineering Research Council of Canada RGPIN-2021-03387
6 · The paper itself

Abstract

Mild traumatic brain injury (mTBI) is neurological impairment induced by biomechanical forces without structural brain damage, currently without an objective diagnostic tool. Downstream injury stems from oxidative damage leading to the production of neurotoxic aldehydes. A collagen-based 3D corticomimetic in vitro model of concussion was developed, confirming aldehyde production following impact. Total aldehyde levels were mapped in vivo following mTBI using a novel CEST-MRI contrast agent, ProxyNA

Identifiers

PMID40604170
PMCPMC12202811

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.