Evidence map›Paper›PMID 40604124›Full record

ArticleScientific reports2025

The gut microbiota is not linked to acute noise-induced hearing loss in C57BL/6 mice.

Kasumi Sato, Katherine Araya, Cathryn Wu, Emily Dong, Riley Watson, Manjit Maskey, Chau D Nguyen, Kamil Khanipov, Qing Yang, Zizhen Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Gut-Ear Axis: From Dysbiosis to Auditory and Vestibular Disorders.International journal of molecular sciences · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kasumi SatoDepartment of Neurobiology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555, USA.
Katherine ArayaDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Cathryn WuDepartment of Neurobiology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555, USA.
Emily DongDepartment of Neurobiology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555, USA.
Riley WatsonDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Manjit MaskeyDepartment of Neurobiology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555, USA.
Chau D NguyenDepartment of Neurobiology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555, USA.
Kamil KhanipovDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Qing YangDepartment of Neurobiology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555, USA.
Zizhen WuDepartment of Neurobiology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555, USA. ziwu@utmb.edu.

Funding

The role of acute excitation of sensory neurons in the development of paclitaxel-induced peripheral neuropathyR01CA273001 · NCI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Qing Yang · 2024 to 2026
$2.0M
Determining the roles of Ca2+-binding proteins in modulation of hair cell mechanotransductionR00DC016328 · NIDCD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WU, ZIZHEN · 2021 to 2023
$982k
NCI NIH HHS R01 CA273001NIDCD NIH HHS R00 DC016328NIH HHS CA273001NIH HHS DC016328U.S. Department of Defense RH220042
6 · The paper itself

Abstract

Noise-induced hearing loss (NIHL) is a widespread auditory disorder in industrialized nations, posing significant global and domestic health concerns. Despite its prevalence, the mechanisms underlying NIHL remain poorly understood, hindering the development of effective therapeutic interventions. Emerging evidence from clinical and animal studies suggests a potential relationship between altered gut microbiota and hearing loss, although causality remains unclear. In this study, we investigated the role of postnatal microbial signals in NIHL pathogenesis using acute noise exposure models in C57BL/6 mice. Our findings indicate that acute noise exposure does not significantly alter gut microbiota composition in this strain and that microbiota depletion does not confer protection against hearing loss following acute acoustic trauma. These results suggest no link between gut microbiota and acute NIHL in C57BL/6 mice.

Indexed as

Gastrointestinal MicrobiomeHearing Loss, Noise-InducedAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLNoiseABRAcuteC57BL/6Germ-freeGut microbiotaNoise-induced hearing loss

Identifiers

PMID40604124
PMCPMC12223080

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.